Gender-specific contributing risk factors and outcome of female cryptococcal meningoencephalitis patients

BMC Infectious Diseases

Table 2 Clinical features and outcome related gender in CM patients

	Male (n = 77)	Female (n = 31)	P
Symptoms
Headache, no. (%)	57 (74.0)	24 (77.4)	0.713
Fever, no. (%)	48 (62.3)	19 (61.3)	0.919
Seizure, no. (%)	5 (6.5)	3 (9.7)	0.687
Dizziness, no. (%)	1 (1.3)	1 (3.2)	0.494
Ataxia, no. (%)	3 (3.9)	1 (3.2)	1
Unconsciousness, no. (%)	11 (14.3)	8 (25.8)	0.155
Psychosis, no. (%)	2 (2.6)	2 (6.5)	0.577
CSF, mean ± SD
Ratio of CSF glucose/Blood glucose, mean ± SD	0.30 ± 0.18	0.28 ± 0.18	0.54
CSF pressure (mmH2O), mean ± SD	266.49 ± 60.13	271.94 ± 49.49	0.66
CSF glucose (mmol/L), mean ± SD	2.08 ± 1.36	1.64 ± 1.01	0.80
CSF protein (g/L), mean ± SD	0.94 ± 1.53	0.86 ± 0.51	0.11
Abnormal EEG^a, no. (%)	17 (68.0)	10 (76.9)	0.71
Abnormal MRI^b, no. (%)	25 (75.8)	9 (60.0)	0.31
Outcome
Hospitalization length (days), mean ± SD	50.71 ± 55.36	53.35 ± 53.93	0.44
Survival time (months), mean ± SD	30.40 ± 45.30	21.22 ± 36.15	0.09
Dead, no. (%)	30 (45.5)	15 (53.6)	0.47

^aAbnormal EEG included 5 cases had normal background with focal slow wave and 5 had diffused slow wave in the background
^bAbnormal MRI included Bubble sign 5 cases (2 at the basal ganglion and 3 at subcortex), hydrocephalus 5 cases and 6 cases with abnormal cerebral lesions (6 cases with more than one abnormal features)