Table 4 Mixed-effects model of the effects of dose occasion, treatment group and covariates on dihydroartemisinin exposure in HIV-1 infected patients
Dose occasion effect (last/first dose occasion) | AUC GMR (95Â % CI) | Cmax GMR (95Â % CI) |
 - Antiretroviral naïve group | 1.30 (1.03–1.64) | 1.12 (0.84–1.49) |
 - Lopinavir group | 0.84 (0.65–1.09) | 0.77 (0.56–1.05) |
Treatment group effect (lopinavir group/naïve group) |  | |
 - 0 to 8 h | 1.73 (1.26–2.37) | 1.73 (1.24–2.43) |
 - 60 to 68 h | 1.12 (0.56–1.55) | 1.19 (0.58–2.57) |