Skip to main content

Table 3 Cox regression analysis of risk factors for drug-induced liver injury in all patients

From: Hepatitis C and not Hepatitis B virus is a risk factor for anti-tuberculosis drug induced liver injury

 

Univariate analysis

Multivariate analysis

 

HR (95 % CI)

P-value

HR (95 % CI)

P-value

Control

Reference

HBV

1.291 (0.635-2.624)

0.481

1.321 (0.612-2.850)

0.479

HCV

3.425 (1.752-6.697)

<0.001

2.623 (1.289-5.338)

0.008

HBV+HCV

9.273 (2.793-30.788)

<0.001

9.401 (2.691-32.841)

<0.001

Age, per year

1.025 (1.007-1.043)

0.005

1.034 (1.013-1.054)

0.001

HCC

3.361 (1.212-9.322)

0.020

1.790 0.598-5.356)

0.298

Baseline LFT

Abnormalitya

2.702 (1.526-4.784)

0.001

2.331 (1.238-4.390)

0.009

  1. HBV: hepatitis B virus, HCV: hepatitis C virus, HCC: Hepatocellular carcinoma, HR: hazards ratio, CI: confidential interval, BMI: body mass index (kg/m2), LFT: liver function test
  2. aBaseline LFT Abnormality: aspartate aminotransferase > 40IU/L or alanine aminotransferase > 40IU/L