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Table 1 Baseline characteristics of all patients and chronic viral hepatitis patients

From: Hepatitis C and not Hepatitis B virus is a risk factor for anti-tuberculosis drug induced liver injury

 

Control, non-CVH (n=251)

CVH

HBV (n=83)

HCV (n=41)

HBV+HCV (n=4)

Age, years

59.3±17.3

50.0±15.1a

59.9±14.9

54.3±9.5

Sex, female

155 (61.8)

61 (73.5)

27 (65.9)

4 (100)

Use of PZA

235 (93.6)

68 (81.9) a

36 (87.8)

3 (75.0)

DM

49 (19.5)

18 (21.7)

17 (41.5) a

2 (50.0)

HCC

1 (0.4)

7 (8.4) a

2 (4.9)

0 (0)

Other malignancy

42 (16.7)

8 (9.8)

2 (4.9)

0 (0)

Alcohol ingestionb

42 (16.7)

9 (10.8)

7 (17.1)

1 (25)

Extrapulomary TB

72 (28.7)

24 (28.9)

8 (19.5)

0 (0)

Past TB history

30 (12.0)

19 (22.9) a

7 (17.1)

2 (50)

BMI >25kg/m2

37 (16.5)

8 (10.3)

6 (15.4)

0 (0)

Liver cirrhosis

3 (1.2)

21 (25.3) a

4 (9.8) a

2 (50) a

CKD

13 (5.2)

3 (3.6)

2 (4.9)

0 (0)

Baseline LFT abnormalityc

27 (10.8)

21 (25.3) a

15 (36.6) a

2 (50)

  1. Data are presented as mean ± standard deviation for continuous data and number (%) for categorical data. HBV: hepatitis B virus, HCV: hepatitis C virus, BMI: body mass index, LFT: liver function test, DM: diabetes mellitus, HCC: Hepatocellular carcinoma, TB: tuberculosis, CKD: Chronic kidney disease, PZA: pyrazinamide
  2. a p-value < 0.05 compared to control group using Fisher’s exact test or Mann-Whitney U test.
  3. bAlcohol ingestion defined as consuming 30 g/day or more for males and 20 g/day or more for females.
  4. cBaseline liver function abnormality was defined as aspartate aminotransferase or alanine aminotransferase over 40 IU/L.