Table 2 Comparative performance of SSM versus LAM, and the combination of LAM and SSM versus SSM alone using the microbiological reference standard
SSM versus LAM | Combined SSM and LAM versus SSM alone | ||||||
|---|---|---|---|---|---|---|---|
N = 457 | SSM only | LAM only | p-value | SSM only | LAM only | SSM plus LAM | p-value |
Sensitivity | 54.9 % | 61.0 % | 0.429 | 54.9 %* | 61.0 % | 74.4 %* | 0.009 |
(95 % CI) | (43.5–65.9) | (49.6-71.6) | (43.5-65.9) | (49.6–71.6) | (63.6-83.4) | ||
n + ve/total | 45/82 | 50/82 | 45/82 | 50/82 | 61/825 | ||
Specificity | 95.7 % | 86.1 % | <0.001 | 95.7 %* | 86.1 % | 84.8 %* | <0.001 |
(95 % CI) | (93.2-97.5) | (82.2-89.5) | (93.2-97.5) | (82.2-89.5) | (80.8-88.3) | ||
n -ve/total | 359/375 | 323/375 | 359/375 | 323/375 | 318/375 | ||
PPV | 73.8 % | 49.0 | 0.007 | 73.8 %* | 49.0 | 51.7 %* | 0.015 |
(95 % CI) | (60.9–84.2) | (39.0-59.1) | (60.9-84.2) | (39.0–59.1) | (42.3-61.0) | ||
NPV | 90.7 % | 91.0 | 0.876 | 90.7 % | 91.0 | 93.8 % | >0.05 |
(95 % CI) | (87.6-93.6) | (87.5-93.8) | (87.6–93.6) | (87.5-93.8) | (90.7-96.1) | ||