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Table 1 Demographics, clinical and microbiological characteristics of study patients stratified by TB diagnostic group

From: Comparative performance characteristics of the urine lipoarabinomannan strip test and sputum smear microscopy in hospitalized HIV-infected patients with suspected tuberculosis in Harare, Zimbabwe

  All Definite TB Probable TB Non-TB P-value
  N = 457 N = 82 N = 115 N = 260  
Demographics      
 Median age (IQR) 37 36 35 38 NS
(31-44) (32-41) (29-44) (31-45)
 Female (%) 241 (53) 41 (50) 63 (55) 123 (52) NS
 Median CD4 count (cells/μL, IQR) 55 41a 43 a 71* <0.0001
(18-153) (15-88) (17-128) (24-180)
 Previous TB (%) 95 (21) 12(15) 26(23) 57(22) NS
Clinical features      
 Cough >2 wks (%) 446 (98) 82(100) 113(98) 251(97) NS
 Drenching night sweats (%) 299 (65) 51(62) 81(70) 167(56) NS
 Weight loss (%) 361 (79) 68(83) 92(80) 201(77) NS
 Fever > 38 °C (%) 334 (73) 68 (82)a 90 (78)a 176(68)* <0.005
 CXR compatible with TB (%) 252 (55) 61(74) 76(66) 115(44) <0.0001
 Commenced on TB Treatment (%) 218 (48) 81(99)a 115(100)a 22(8)* <0.0001
TB treatment based on: n = 218 n = 81 n = 115 n = 22  
 Empirically (%) 87(40) 11(14)a 60(52)a 16(73)* <0.0001
 LAM positive grades 1 and 2b 104b (48) 50(62)* 48(42)* 6(27)* <0.005
 SSM 16(7) 11(14)* 5(4)* 0(0) <0.005
 Culture 11(5) 9(11)* 2(2)* 0(0) <0.005
TB symptoms at 2 months for those on treatment n = 218 n = 81 n = 115 n = 22  
 Improved TB symptoms on treatment at 2 month follow-up 137(63) 54(66)* 83(72)* 0(0) 0.003
 Died of TB before 2 months follow-up 61(28) 19(23)a 32(28)a 10(45) 0.023
 Lost to follow-up on treatment 2(1) 1(1) 0(0) 1(5) NS
  1. CXR Chest x-ray, LAM urine Lipoarabinomannan strip test, SSM sputum smear microscopy
  2. P-values indicate significant differences between patient groups (marked with * to indicate comparison group) for different patients characteristics
  3. * - Significantly different (p ≤ 0.05). a - Significant difference after combining two groups
  4. NS Not significant (p > 0.05). b102 patients had LAM ≥2 positivity and 2 had grade 1 and attending clinicians insisted on commencing anti-TB treatment for these 2 patients