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Table 4 Carriage of specific pneumococcal subtypes in children with asthma, by pneumococcal vaccination status

From: Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine

  Vaccinated with PCV7, n (%) Not vaccinated with PCV7, n (%) Crude OR (95 % CI) OR (95 % CI)a
Total carriers 93 99   
Carriers of serotypes not included in PCV13 4 (4.3) 6 (6.0) 0.84 (0.23–3.07) 0.97 (0.25–3.77)
Carriers of PCV13 serotypes
 1 32 (34.4) 29 (29.2) 1.40 (0.80–2.47) 1.23 (0.69–2.21)
 2 41 (44.1) 28 (28.2) 1.86 (1.08–3.21) 1.64 (0.93–2.89)
 ≥3 16 (17.2) 36 (36.6) 0.57 (0.30–1.08) 0.46 (0.23–0.91)
Carriers of different PCV13 serotypes
 Serotype 1 1 (1.0) 2 (2.0) 0.58 (0.05–6.47) 0.56 (0.05–6.40)
 Serotype 3 12 (13.0) 11 (11.1) 1.29 (0.56–3.00) 1.18 (0.50–2.80)
 Serotype 4 26 (28.0) 39 (39.4) 0.75 (0.43–1.28) 0.62 (0.36–1.09)
 Serotype 5 15 (16.1) 23 (23.2) 0.74 (0.38–1.47) 0.68 (0.33–1.38)
 Serotype 6A 5 (5.4) 6 (6.1) 0.97 (0.29–3.24) 0.65 (0.18–2.40)
 Serotype 6B 0 (0.0) 3 (3.0) NE NE
 Serotype 7 F 2 (2.1) 4(4.0) 0.58 (0.10–3.20) 0.60 (0.10–3.49)
 Serotype 9 V 18 (19.3) 22 (22.1) 0.95 (0.49–1.83) 0.95 (0.48–1.87)
 Serotype 14 0 (0.0) 1 (1.0) NE NE
 Serotype 18C 0 (0.0) 0 (0.0) NE NE
 Serotype 19A 3 (3.2) 7 (7.1) 0.49 (0.13–1.94) 0.43 (0.11–1.77)
 Serotype 19 F 83 (89.2) 84 (84.9) 1.27 (0.86–1.88) 1.13 (0.75–1.70)
 Serotype 23 F 2 (2.1) 2 (2.0) 1.17 (0.16–8.40) 0.83 (0.11–6.26)
  1. Reference category is non-carrier of corresponding serotypes
  2. 95 % CI 95 % confidence interval; NE not estimable; OR odds ratio; PCV7 7-valent pneumococcal conjugate vaccine; PCV13 13-valent pneumococcal conjugate vaccine
  3. aORs adjusted for age (as a continuous term), gender, ethnicity, number of sibling, and parental smoking