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Table 3 Risk for clustering of Mtb isolates stratified by drug-resistant pattern, gene mutation and non-bacterial factors among the TB patients with single strain infection

From: Drug resistance characteristics and cluster analysis of M. tuberculosis in Chinese patients with multiple episodes of anti-tuberculosis treatment

 

No. of isolates

Unadjusted

Adjusted by age, sex and areas

Total

Clustered (%)

OR*

95 % CI*

OR*

95 % CI*

Socio and clinical factors

 Sex

  Female

33

7 (21.2)

1

 

1

 

  Male

101

26 (25.7)

1.29

0.469–3.931

1.20

0.435–4.041

 Treatment episode

  =2

76

13 (17.1)

1

 

1

 

  ≥3

58

20 (34.5)

2.55

1.060–6.238**

2.41

1.012–6.543**

 Sputum smear

  Negative

9

2 (22.2)

1

 

1

 

  Positive

125

31 (24.8)

1.15

0.205–11.94

1.12

0.201–12.02

 Drug resistance and genetic mutation:

  Other DR

60

9 (15.0)

1

 

1

 

  MDR

70

24 (34.3)

2.45

1.008–6.363**

2.43

1.007–6.471**

  preXDR/XDR

25

6 (24.0)

1.79

0.456–6.520

1.81

0.451–6.522

 Drug resistant isolates with mutation in:

  WT

38

7 (18.4)

1

 

1

 

  katG

59

12 (20.3)

1.33

0.421–4.470

1.28

0.419–4.451

  rpoB

55

21 (38.2)

2.74

0.943–8.622

2.64

0.873–8.953

  pncA

39

8 (20.5)

1.14

0.317–4.197

1.15

0.313–4.221

  gyrA

11

3 (27.3)

1.66

0.224–9.531

1.53

0.214–9.524

  rrs

7

1 (14.3)

0.74

0.014–7.907

0.71

0.010–8.123

  eis

4

0 (0)

-

 

-

 
  1. MDR multidrug resistance, XDR extensively drug resistance
  2. *OR and 95 % CI were calculated in the binary logistic regression model
  3. **p < 0.05