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Table 3 Risk for clustering of Mtb isolates stratified by drug-resistant pattern, gene mutation and non-bacterial factors among the TB patients with single strain infection

From: Drug resistance characteristics and cluster analysis of M. tuberculosis in Chinese patients with multiple episodes of anti-tuberculosis treatment

  No. of isolates Unadjusted Adjusted by age, sex and areas
Total Clustered (%) OR* 95 % CI* OR* 95 % CI*
Socio and clinical factors
 Sex
  Female 33 7 (21.2) 1   1  
  Male 101 26 (25.7) 1.29 0.469–3.931 1.20 0.435–4.041
 Treatment episode
  =2 76 13 (17.1) 1   1  
  ≥3 58 20 (34.5) 2.55 1.060–6.238** 2.41 1.012–6.543**
 Sputum smear
  Negative 9 2 (22.2) 1   1  
  Positive 125 31 (24.8) 1.15 0.205–11.94 1.12 0.201–12.02
 Drug resistance and genetic mutation:
  Other DR 60 9 (15.0) 1   1  
  MDR 70 24 (34.3) 2.45 1.008–6.363** 2.43 1.007–6.471**
  preXDR/XDR 25 6 (24.0) 1.79 0.456–6.520 1.81 0.451–6.522
 Drug resistant isolates with mutation in:
  WT 38 7 (18.4) 1   1  
  katG 59 12 (20.3) 1.33 0.421–4.470 1.28 0.419–4.451
  rpoB 55 21 (38.2) 2.74 0.943–8.622 2.64 0.873–8.953
  pncA 39 8 (20.5) 1.14 0.317–4.197 1.15 0.313–4.221
  gyrA 11 3 (27.3) 1.66 0.224–9.531 1.53 0.214–9.524
  rrs 7 1 (14.3) 0.74 0.014–7.907 0.71 0.010–8.123
  eis 4 0 (0) -   -  
  1. MDR multidrug resistance, XDR extensively drug resistance
  2. *OR and 95 % CI were calculated in the binary logistic regression model
  3. **p < 0.05