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Table 2 Correlation between cytokine transcript levels in PBMC and liver biopsy grading scores and ALT activity in 22 patients with chronic hepatitis C prior to the initiation of antiviral therapy

From: The correlation between pretreatment cytokine expression patterns in peripheral blood mononuclear cells with chronic hepatitis c outcome

Cytokinea Liver histology Grading ALT activity in serum
Spearman r Statistical significance Spearman r Statistical significance
IL–1α 0.34 NS 0.62 0.025
IL–4 0.31 NS 0.66 0.002b
IL–6 0.47 0.05 0.46 0.050
IL–10 0.18 NS 0.59 0.005b
IL–12 0.27 NS 0.49 0.028
IL–15 0.19 NS 0.64 0.007b
GM–CSF 0.43 NS 0.49 0.030
M–CSF 0.67 0.010 0.56 0.040
MCP–2 0.28 NS 0.54 0.009b
TGF–β 0.39 NS 0.59 0.004b
  1. aOnly cytokines with p≤ 0.05 are listed
  2. bstatistically significant (p≤ 0.05) using Benjamini–Hochberg procedure to correct for multiple testing [24]