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Table 6 Fatalities in five out of 47 patients with PCR-confirmed influenza in Bavarian PICUs, 2010–2013

From: Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13

Patient PICU admittance (season) Age (years) Influenza type/subtype Co-pathogen(s) detecteda Underlying chronic condition Influenza vaccination Complications Antiviral treatment (days) Antibiotics i.v. (days) Cause of death
1 2010/11 10 A(H1N1)pdm09 Escherichia coli Obesity No ARDS, sepsis, convulsion (encephalitis suspected) Acyclovir (2) Yes (2) ARDS, Sepsis
2 2010/11 4 A(H1N1)pdm09 Streptococcus sp., Candida sp. Neurologic No Pneumonia, secondary bacterial pneumonia, pleural effusion No Yes (10) Circulatory insufficiency
Pulmonal
Pre-term birth
3 2010/11 4 A(H1N1)pdm09 RSV Pseudomomas aeruginosa Neurologic No Pneumonia, secondary bacterial pneumonia, ARDS No Yes (19) ARDS
Pulmonal
Pre-term birth
Obesity
4 2012/13 11 A(H1N1)pdm09 RSV, Candida sp. Neurologic No Pneumonia, secondary bacterial pneumonia, bronchitis, ARDS, sepsis Oseltamivir (5) Yes (22) ARDS, circulatory insufficiency
Pulmonal
5 2012/13 11 A(H1N1)pdm09 None Neurologic No Pneumonia No Yes (4) Respiratory failure
Pulmonal
  1. aViral co-infections were detected either by local PCR or central multiplex PCR; bacteria and fungi were identified from blood culture or tracheal aspirates (intratracheal ventilation)