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Table 5 Treatment and outcome of PCR-confirmed influenza patients in Bavarian PICUs, 2010–2013. Data are shown by virus type/subtype (n = 47)a

From: Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13

 

Influenza type/subtype

Comparison of seasons

A(H1N1)pdm09c

Treatment

All

A

A(H1N1)pdm09

A(H3N2)

A (subtype n.a.)

B

S1 vs S3

 

N = 47

N = 40

N = 32

N = 4

N = 4

N = 7

p-value*

Antiviral drugsb; n (%)

13 (27.7)

12 (30.0)

9 (28.1)

1 (25.0)

2 (50.0)

1 (14.3)

1.000

Antibiotics i.v.; n (%)

34 (72.3)

31 (77.5)

25 (78.1)

2 (50.0)

4 (100.0)

3 (42.9)

0.676

Antipyretics; n (%)

33 (70.2)

28 (70.0)

22 (68.8)

2 (50.0)

4 (100.0)

5 (71.4)

0.452

Catecholamines; n (%)

13 (27.7)

13 (32.5)

11 (34.4)

1 (25.0)

1 (25.0)

0 (0.0)

1.000

Inhalation therapy; n (%)

13 (27.7)

13 (32.5)

11 (34.4)

2 (50.0)

0 (0.0)

0 (0.0)

1.000

Oxygen; n (%)

31 (66.0)

28 (70.0)

20 (62.5)

4 (100.0)

4 (100.0.)

3 (42.9)

0.275

Intratracheal ventilation; n (%)

15 (31.9)

14 (35.0)

12 (37.5)

1 (25.0)

1 (25.0)

1 (14.3)

1.000

CPAP; n (%)

11 (23.4)

9 (22.5)

7 (21.9)

0 (0.0)

2 (50.0)

2 (28.6)

0.084

Other; n (%)

14 (29.8)

13 (32.5)

10 (31.3)

2 (50.0)

1 (25.0)

1 (14.3)

0.247

Outcome

       

 Sequelae; n (%)

5 (10.6)

4 (10.0)

3 (9.4)

1 (25.0)

0 (0.0)

1 (14.3)

0.548

 Death; n (%)

5 (10.6)

5 (12.5)

5 (15.6)

0 (0.0)

0 (0.0)

0 (0.0)

1.000

  1. n.a. not available, vs versus, i.v. intravenous
  2. *Fisher’s Exact test or Mann–Whitney U-test, respectively
  3. aClinical data was not available for one influenza A(H1N1)pdm09 and three influenza B patients
  4. bOseltamivir (n = 8), oseltamivir plus acyclovir (n = 1), acyclovir (n = 3), gancyclovir plus valgancyclovir (n = 1)
  5. cComparison restricted to influenza A(H1N1)pdm09 patients from Season 1 (S1; Oct10–Sep 11; n = 18) and Season 3 (S3; Oct12–Sep 13; n = 13)