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Table 4 Diagnoses/complications of PCR-confirmed influenza patients in Bavarian PICUs, 2010–2013. Data are shown by virus type/subtype (n = 47)a

From: Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13

 

Influenza type/subtype

Comparison of seasons

A(H1N1)pdm09b

Complications

All patients

A

A(H1N1)pdm09

A(H3N2)

A (subtype n.a.)

B

S1 vs S3

N = 47

N = 40

N = 32

N = 4

N = 4

N = 7

p-value*

At least 1 specific complication; n (%)

42 (89.4)

36 (90.0)

29 (90.6)

3 (75.0)

4 (100.0)

6 (85.7)

0.497

Influenza-associated pneumonia; n (%)

29 (61.7)

26 (65.0)

22 (68.8)

1 (25.0)

3 (75.0)

3 (42.9)

1.000

Bronchitis/bronchiolitis; n (%)

15 (31.9)

13 (32.5)

8 (25.0)

3 (75.0)

2 (50.0)

2 (28.6)

0.004

Secondary bacterial pneumonia; n (%)

12 (25.5)

10 (25.0)

10 (31.3)

0 (0.0)

0 (0.0)

2 (28.6)

0.452

ARDS; n (%)

10 (21.3)

9 (22.5)

7 (21.9)

2 (50.0)

0 (0.0)

1 (14.3)

0.099

Sepsis; n (%)

6 (12.8)

6 (15.0)

4 (12.5)

1 (25.0)

1 (25.0)

0 (0.0)

1.000

Febrile convulsions; n (%)

3 (6.4)

2 (5.0)

2 (6.3)

0 (0.0)

0 (0.0)

1 (14.3)

1.000

Encephalitis/encephalopathy; n (%)

1 (2.1)

1 (2.5)

1 (3.1)

0 (0.0)

0 (0.0)

0 (0.0)

1.000

Laryngitis/pseudocroup; n (%)

1 (2.1)

1 (2.5)

1 (3.1)

0 (0.0)

0 (0.0)

0 (0.0)

1.000

Otherc; n (%)

6 (12.8)

5 (12.5)

5 (15.6)

0 (0.0)

0 (0.0)

1 (14.3)

1.000

  1. n.a. not available, vs versus
  2. *Fisher’s Exact test
  3. aClinical data was not available for one influenza A(H1N1)pdm09 and three influenza B patients
  4. bComparison restricted to influenza A(H1N1)pdm09 patients from Season 1 (S1; Oct10–Sep 11; n = 18) and Season 3 (S3; Oct12–Sep 13; n = 13)
  5. cOther complications, excluding the pre-defined complications otitis media, status asthmaticus, and myocarditis (for these pre-defined complications, no case was reported)