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Table 3 Underlying chronic medical conditions of PCR-confirmed influenza patients in Bavarian PICUs, 2010–2013. Data are shown by virus type/subtype (n = 47)a

From: Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13

  Influenza type/subtype Comparison of seasons
A(H1N1)pdm09c
Underlying medical conditions All patients A A(H1N1)pdm09 A(H3N2) A (subtype n.a.) B S1 vs S3
N = 47 N = 40 N = 32 N = 4 N = 4 N = 7 p-value*
At least one medical condition; n (%) 36 (76.6) 32 (80.0) 24 (75.0) 4 (100.0) 4 (100.0) 4 (57.1) 0.667
Selected conditions        
 - Neurological disease; n (%) 16 (34.0) 14 (35.0) 13 (40.6) 1 (25.0) 0 (0.0) 2 (28.6) 1.000
 - Chronic lung diseaseb; n (%) 12 (25.5) 12 (30.0) 11 (34.4) 0 (0.0) 1 (25.0) 0 (0.0) 1.000
 - Pre-term birth; n (%) 10 (21.3) 9 (22.5) 8 (25.0) 1 (25.0) 0 (0.0) 1 (14.3) 0.210
 - Cardiac malformation; n (%) 8 (17.0) 8 (20.0) 3 (9.4) 3 (75.0) 2 (50.0) 0 (0.0) 0.558
 - Obesity; n (%) 5 (10.6) 5 (12.5) 3 (9.4) 0 (0.0) 2 (50.0) 0 (0.0) 0.245
 - Genetic disorder; n (%) 4 (8.5) 3 (7.5) 3 (9.4) 0 (0.0) 0 (0.0) 1 (14.3) 0.558
 - Immunocompromised; n (%) 4 (8.5) 2 (5.0) 0 (0.0) 1 (25.0) 1 (25.0) 2 (28.6) n.a.
 - Renal disease; n (%) 1 (2.1) 1 (2.5) 1 (3.1) 0 (0.0) 0 (0.0) 0 (0.0) 0.419
 - Other underlying conditions; n (%) 9 (19.1) 8 (20.0) 5 (15.6) 2 (50.0) 1 (25.0) 1 (14.3) 0.134
  1. n.a. not available, vs versus
  2. *Fisher’s Exact test or Mann–Whitney U-test, respectively
  3. aClinical data was not available for one influenza A(H1N1)pdm09 and three influenza B patients
  4. bIncluding asthma, broncho-pulmonary dysplasia, other chronic lung disease
  5. cComparison restricted to influenza A(H1N1)pdm09 patients from Season 1 (S1; Oct10–Sep 11; n = 18) and Season 3 (S3; Oct12–Sep 13; n = 13)