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Table 3 Underlying chronic medical conditions of PCR-confirmed influenza patients in Bavarian PICUs, 2010–2013. Data are shown by virus type/subtype (n = 47)a

From: Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13

 

Influenza type/subtype

Comparison of seasons

A(H1N1)pdm09c

Underlying medical conditions

All patients

A

A(H1N1)pdm09

A(H3N2)

A (subtype n.a.)

B

S1 vs S3

N = 47

N = 40

N = 32

N = 4

N = 4

N = 7

p-value*

At least one medical condition; n (%)

36 (76.6)

32 (80.0)

24 (75.0)

4 (100.0)

4 (100.0)

4 (57.1)

0.667

Selected conditions

       

 - Neurological disease; n (%)

16 (34.0)

14 (35.0)

13 (40.6)

1 (25.0)

0 (0.0)

2 (28.6)

1.000

 - Chronic lung diseaseb; n (%)

12 (25.5)

12 (30.0)

11 (34.4)

0 (0.0)

1 (25.0)

0 (0.0)

1.000

 - Pre-term birth; n (%)

10 (21.3)

9 (22.5)

8 (25.0)

1 (25.0)

0 (0.0)

1 (14.3)

0.210

 - Cardiac malformation; n (%)

8 (17.0)

8 (20.0)

3 (9.4)

3 (75.0)

2 (50.0)

0 (0.0)

0.558

 - Obesity; n (%)

5 (10.6)

5 (12.5)

3 (9.4)

0 (0.0)

2 (50.0)

0 (0.0)

0.245

 - Genetic disorder; n (%)

4 (8.5)

3 (7.5)

3 (9.4)

0 (0.0)

0 (0.0)

1 (14.3)

0.558

 - Immunocompromised; n (%)

4 (8.5)

2 (5.0)

0 (0.0)

1 (25.0)

1 (25.0)

2 (28.6)

n.a.

 - Renal disease; n (%)

1 (2.1)

1 (2.5)

1 (3.1)

0 (0.0)

0 (0.0)

0 (0.0)

0.419

 - Other underlying conditions; n (%)

9 (19.1)

8 (20.0)

5 (15.6)

2 (50.0)

1 (25.0)

1 (14.3)

0.134

  1. n.a. not available, vs versus
  2. *Fisher’s Exact test or Mann–Whitney U-test, respectively
  3. aClinical data was not available for one influenza A(H1N1)pdm09 and three influenza B patients
  4. bIncluding asthma, broncho-pulmonary dysplasia, other chronic lung disease
  5. cComparison restricted to influenza A(H1N1)pdm09 patients from Season 1 (S1; Oct10–Sep 11; n = 18) and Season 3 (S3; Oct12–Sep 13; n = 13)