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Table 2 Univariate associations between emergence of and episode of hepatic decompensation and/or HCC and other parameters (n = 275)

From: Progression of liver stiffness predicts clinical events in HIV/HCV-coinfected patients with compensated cirrhosis

Parameter

Category

No. (%) with decompensation

P Bivariate (Log rank test)

Sex

Male

16 (6)

 

Female

3 (10)

0.4

Age

< 44 years

6 (5)

 

≥ 44 years

13 (8)

0.2

Hepatitis B virus surface antigen

Negative

17 (6)

 

Positive

2 (25)

0.15

HCV genotype

1–4

13 (6)

 

2–3

6 (9)

0.4

HCV RNA load (log10 IU/mL)a

< 6.7

13 (7)

 

≥ 6.7

5 (8)

0.5

Therapy against HCV during follow-up

No therapy or therapy without SVRb

16 (6)

 

SVRb

3 (11)

0.6

CD4 cell count (cells/mm3)

< 200

5 (8)

 

≥ 200

14 (6)

0.5

Platelet count (/mm3)

< 150.000

16 (9)

 

≥ 150.000

3 (3)

0.061

APRIc score

< 1.5

9 (7)

 

≥ 1.5

10 (7)

0.9

Child-Turcotte-Pugh class

A

15 (6)

 

B

4 (15)

0.002

MELDd scoree

< 14

17 (7)

 

≥ 14

0 (0)

0.6

Liver stiffness (kPa)

< 21

7 (5)

 

≥ 21

12 (9)

0.18

Progression of liver stiffness ≥ 30 % from baselinef

No

5 (3)

 

Yes

10 (13)

0.011

  1. aAvailable in 254 patients
  2. bSVR: Sustained virological response
  3. cAPRI: AST platelet ratio index
  4. dModel for end-stage liver disease
  5. eAvailable in 251 patients
  6. fEvaluable in 247 patients