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Table 6 Association of IL-23R polymorphisms and pulmonary infiltration and cavitary formation in pulmonary TB patients

From: The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs

dbSNP ID/

Genotype

Cavitary formation (N = 250)

OR (95 % CI)

Pulmonary infiltration (N = 250)

OR (95 % CI)

  

No Cavity lesion

Cavity lesion

 

≤ 1/3 of one lung

>1/3 of one lung

 
  

N = 179 n (%)

N = 71 n (%)

 

N = 138 n (%)

N = 112 n (%)

 

rs1884444

TT

88 (49.2)

15 (21.1)

1

58 (42.0)

45 (40.2)

1

 

GG + GT

91 (50.8)

56 (78.9)

3.61 (1.90–6.85)

80 (58.0)

67 (59.8)

1.08 (0.65–1.79)

rs10889664

CC

87 (48.6)

36 (50.7)

1

68 (49.3)

55 (49.1)

1

 

TT + CT

92 (51.4)

35 (49.3)

0.92 (0.53–1.59)

70 (50.7)

57 (50.9)

1.01 (0.61–1.66)

rs11465788

TT

74 (41.3)

31 (43.7)

1

57 (41.3)

48 (42.9)

1

 

CC + CT

105 (58.7)

40 (56.3)

0.91 (0.52–1.59)

81 (58.7)

64 (57.1)

0.94 (0.57–1.55)

rs7518660

GG

7 (4.1)

5 (7.0)

1

7 (5.1)

5 (4.5)

1

 

AA + AG

172 (95.9)

66 (93.0)

0.54 (0.17–1.75)

131 (94.9)

107 (95.5)

1.14 (0.35–3.71)

rs11465802

CC

72 (40.2)

30 (42.3)

1

56 (40.6)

46 (41.1)

1

 

AA + AC

107 (59.8)

41 (57.7)

0.92 (0.53–1.61)

82 (59.4)

66 (58.9)

0.98 (0.59–1.63)

rs10889677

AA

39 (21.8)

14 (19.7)

1

31 (22.5)

22 (19.6)

1

 

CC + AC

140 (78.2)

57 (80.3)

1.13 (0.57–2.25)

107 (77.5)

90 (80.4)

1.19 (0.64–2.19)

CNV

CN = 2

144 (80.4)

56 (78.9)

1

109 (79.0)

91 (81.3)

1

 

CN = 1, 3, 4

35 (19.6)

15 (21.1)

1.10 (0.56–2.17)

29 (21.0)

21 (18.7)

0.87 (0.46–1.62)

  1. OR odds ratio, CI confidence interval