Table 4 Human papillomavirus (HPV) genotyping agreement for paired cytology and tissue specimensa tested with different genotyping methods
From: Detection of HPV DNA in paraffin-embedded cervical samples: a comparison of four genotyping methods
Overall agreement | Onclarity | Inno-LiPA | Linear Array | SPF-LiPA25 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
with cytology | N (%) | N (%) | N (%) | N (%) | ||||||||
Identical | 32 (53.3) | 34 (56.7) | 32 (53.3) | 37 (61.7) | ||||||||
Compatible | 19 (31.7) | 17 (28.3) | 15 (25.0) | 20 (33.3) | ||||||||
Discrepant | 9 (15.0) | 9 (15.0) | 13 (21.7) | 3 (5.0) | ||||||||
HPV type | %a | kappa | p | %b | kappa | p | %a | kappa | p | %a | kappa | p |
Any oncogenic typec | 90.0 | NA | 85.0 | NA | 80.0 | NA | 95.0 | NA | ||||
Single probe | ||||||||||||
HPV 16 | 83.3 | 0.7 | 0.1 | 88.3 | 0.8 | 0.02 | 86.7 | 0.7 | 0.01 | 88.3 | 0.8 | 0.5 |
HPV 18 | 95 | 0.8 | 1.0 | 96.7 | 0.9 | 0.5 | 93.3 | 0.7 | 0.1 | 98.3 | 0.9 | 1.0 |
HPV 31 | 95 | 0.8 | 1.0 | 98.3 | 0.9 | 1.0 | 96.7 | 0.8 | 0.5 | 98.3 | 0.9 | 1.0 |
HPV 33 | NA | 100 | 1.0 | NA | 100 | 1.0 | NA | 100 | 1.0 | NA | ||
HPV 35 | NA | 98.3 | NA | 98.3 | NA | 98.3 | NA | |||||
HPV 39 | NA | 96.7 | 0.7 | 0.5 | 96.7 | 0.7 | 0.5 | 96.7 | 0.7 | 0.5 | ||
HPV 45 | 91.7 | 0.6 | 0.1 | 90.0 | 0.4 | 0.03 | 91.7 | 0.5 | 0.1 | 95.0 | 0.7 | 0.3 |
HPV 51 | 91.7 | 0.3 | 0.1 | 93.3 | 0.5 | 0.1 | 91.7 | 0.3 | 0.1 | 93.3 | 0.5 | 0.1 |
HPV 52d | 98.3 | 0.9 | 1.0 | 95.0 | 0.6 | 0.3 | 93.3 | 0.5 | 0.1 | 96.7 | 0.8 | 1.0 |
HPV 56 | NA | 95.0 | 0.4 | 0.3 | 95.0 | 0.4 | 0.3 | 95.0 | 0.4 | 0.3 | ||
HPV 58 | NA | 96.7 | 0.7 | 0.5 | 96.7 | 0.7 | 0.5 | 96.7 | 0.7 | 0.5 | ||
HPV 59 | NA | NA | 100 | 1.0 | NA | 98.3 | 0.7 | 1.0 | ||||
HPV 66 | NA | NA | NA | 95.0 | 0.4 | 0.3 | ||||||
HPV 68 | NA | NA | 98.3 | 0.7 | 1.0 | NA | ||||||