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Table 2 Human papillomavirus (HPV) genotyping results for paired cytology and tissue specimensa by genotyping method (%)

From: Detection of HPV DNA in paraffin-embedded cervical samples: a comparison of four genotyping methods

 

Cytology

FFPE samples

HPV, type

Linear Array

Onclarity

Inno-LiPA

Linear Array

SPF-LiPA25

Any oncogenicb

60 (100.0)

54 (90.0)

51 (85.0)

48 (80.0)

57 (95.0)

Single probes

     

HPV 16

32 (53.3)

26 (43.3)

25 (41.7)

24 (40.0)

29 (48.3)

HPV 18

9 (15.0)

8 (13.3)

7 (11.7)

5 (8.3)

8 (13.3)

HPV 31

8 (13.3)

7 (11.7)

7 (11.7)

6 (10.0)

7 (11.7)

HPV 33

2 (3.3)

NA

2 (3.3)

2 (3.3)

2 (3.3)

HPV 35

1 (1.7)

NA

0

0

0

HPV 39

4 (6.7)

NA

2 (3.3)

2 (3.3)

2 (3.3)

HPV 45

8 (13.3)

5 (8.3)

2 (3.3)

3 (5.0)

5 (8.3)

HPV 51

6 (10.0)

1 (1.7)

2 (3.3)

1 (1.7)

2 (3.3)

HPV 52

NA

5 (8.3)

3 (5.0)

NA

6 (10.0)

HPV 56

4 (6.7)

NA

1 (1.7)

1 (1.7)

1 (1.7)

HPV 58

5 (8.3)

NA

3 (5.0)

3 (5.0)

3 (5.0)

HPV 59

2 (3.3)

NA

0

2 (3.3)

1 (1.7)

HPV 66

4 (6.7)

NA

0

0

1 (1.7)

HPV 68

2 (3.3)

NA

0

1 (1.7)

NA

Combined probes

     

52/33/35/58c

6 (10.0)

NA

NA

2 (3.3)

NA

33/58

NA

5 (8.3)

NA

NA

NA

35/39/68

NA

3 (5.0)

NA

NA

NA

56/59/66

NA

4 (6.7)

NA

NA

NA

68/73

NA

NA

NA

NA

2 (3.3)

Multiple infectionsd

21(35.0)

10 (16.6)

3 (5.0)

4 (6.7)

11 (18.3)

  1. a Genotyping results for 60 paired cytology- and formalin-fixed and paraffin embedded (FFPE) specimens in the SUCCEED study; Onclarity, The BD Onclarity â„¢ HPV Assay; Inno-LiPA, The Inno-LiPA system; Linear Array, The PGMY09/11 Linear Array, and SPF-LiPA25, The SPF10-DEIA, LiPA25 (version 1); b includes a specimen positive for any of the 14 HPV types; c HPV 52 was positively identified by the Linear array test when the presence of HPV 33, 35, and 58 was excluded; d Multiple infections included individual HPV types or combined types; NA, not applicable