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Table 2 Human papillomavirus (HPV) genotyping results for paired cytology and tissue specimensa by genotyping method (%)

From: Detection of HPV DNA in paraffin-embedded cervical samples: a comparison of four genotyping methods

  Cytology FFPE samples
HPV, type Linear Array Onclarity Inno-LiPA Linear Array SPF-LiPA25
Any oncogenicb 60 (100.0) 54 (90.0) 51 (85.0) 48 (80.0) 57 (95.0)
Single probes      
HPV 16 32 (53.3) 26 (43.3) 25 (41.7) 24 (40.0) 29 (48.3)
HPV 18 9 (15.0) 8 (13.3) 7 (11.7) 5 (8.3) 8 (13.3)
HPV 31 8 (13.3) 7 (11.7) 7 (11.7) 6 (10.0) 7 (11.7)
HPV 33 2 (3.3) NA 2 (3.3) 2 (3.3) 2 (3.3)
HPV 35 1 (1.7) NA 0 0 0
HPV 39 4 (6.7) NA 2 (3.3) 2 (3.3) 2 (3.3)
HPV 45 8 (13.3) 5 (8.3) 2 (3.3) 3 (5.0) 5 (8.3)
HPV 51 6 (10.0) 1 (1.7) 2 (3.3) 1 (1.7) 2 (3.3)
HPV 52 NA 5 (8.3) 3 (5.0) NA 6 (10.0)
HPV 56 4 (6.7) NA 1 (1.7) 1 (1.7) 1 (1.7)
HPV 58 5 (8.3) NA 3 (5.0) 3 (5.0) 3 (5.0)
HPV 59 2 (3.3) NA 0 2 (3.3) 1 (1.7)
HPV 66 4 (6.7) NA 0 0 1 (1.7)
HPV 68 2 (3.3) NA 0 1 (1.7) NA
Combined probes      
52/33/35/58c 6 (10.0) NA NA 2 (3.3) NA
33/58 NA 5 (8.3) NA NA NA
35/39/68 NA 3 (5.0) NA NA NA
56/59/66 NA 4 (6.7) NA NA NA
68/73 NA NA NA NA 2 (3.3)
Multiple infectionsd 21(35.0) 10 (16.6) 3 (5.0) 4 (6.7) 11 (18.3)
  1. a Genotyping results for 60 paired cytology- and formalin-fixed and paraffin embedded (FFPE) specimens in the SUCCEED study; Onclarity, The BD Onclarity ™ HPV Assay; Inno-LiPA, The Inno-LiPA system; Linear Array, The PGMY09/11 Linear Array, and SPF-LiPA25, The SPF10-DEIA, LiPA25 (version 1); b includes a specimen positive for any of the 14 HPV types; c HPV 52 was positively identified by the Linear array test when the presence of HPV 33, 35, and 58 was excluded; d Multiple infections included individual HPV types or combined types; NA, not applicable