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Table 3 Cone diagnoses in histologically proven CIN III lesions (biopsy) according to HPV subtype and biopsy-cone interval

From: CIN III lesions and regression: retrospective analysis of 635 cases

  Biopsy-cone interval  
  <6.1 Weeks 6.14–12 Weeks >12 Weeks Total
HPV 16+
≤ CIN I 0 0 0 0
 CIN II 4 (5.8 %) 2 (3.1 %) 6 (9.4 %) 12 (6.1 %)
 CIN III 65 (94.2 %) 62 (96.2 %) 58 (90.6 %) 185 (93.9 %)
Total 100 175 255 197
HPV-HR pos. but HPV16 neg
≤ CIN I 0 1 (2.1 %) 2 (4.4 %) 3 (2.0 %)
 CIN II 2 (3.6 %) 3 (6.3 %) 5 (11.1 %) 10 (6.8 %)
 CIN III 53 (96.4 %) 44 (91.7 %) 38 (84.4 %) 135 (91.2 %)
Total 55 48 45 148
  1. Subanalysis of only those 345 cases with known HPV subtype (16, 18, or other) according to biopsy-cone intervals. CIN I and less were rated as “regression” and CIN II/CIN III as “non-regression”