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Table 3 Cone diagnoses in histologically proven CIN III lesions (biopsy) according to HPV subtype and biopsy-cone interval

From: CIN III lesions and regression: retrospective analysis of 635 cases

 

Biopsy-cone interval

 
 

<6.1 Weeks

6.14–12 Weeks

>12 Weeks

Total

HPV 16+

≤ CIN I

0

0

0

0

 CIN II

4 (5.8 %)

2 (3.1 %)

6 (9.4 %)

12 (6.1 %)

 CIN III

65 (94.2 %)

62 (96.2 %)

58 (90.6 %)

185 (93.9 %)

Total

100

175

255

197

HPV-HR pos. but HPV16 neg

≤ CIN I

0

1 (2.1 %)

2 (4.4 %)

3 (2.0 %)

 CIN II

2 (3.6 %)

3 (6.3 %)

5 (11.1 %)

10 (6.8 %)

 CIN III

53 (96.4 %)

44 (91.7 %)

38 (84.4 %)

135 (91.2 %)

Total

55

48

45

148

  1. Subanalysis of only those 345 cases with known HPV subtype (16, 18, or other) according to biopsy-cone intervals. CIN I and less were rated as “regression” and CIN II/CIN III as “non-regression”