CIN III lesions and regression: retrospective analysis of 635 cases

BMC Infectious Diseases

Table 2 a,b,c Regression and non-regression in CIN III according to different time intervals

a	Biopsy—cone intervals using 33 % percentile of this study
Follow-up	0–6.1 weeks	6.14–12 weeks	>12 weeks	Total
Non-Regression	215 (34.3 %)	210 (33.5 %)	202 (32.2 %)	627 (98.74 %)
Regression	0 (0 %)	2 (0.9 %)	6 (2.9 %)	8 (1.26 %)
Total	215 (33.8 %)	212 (33.4 %)	208 (32.8 %)	635 (100 %)
b	Biopsy—cone intervals according to Munk et. al. ([8])
Follow-up	0–5.4 weeks	5.4–8.9 weeks	>8.9 weeks	Total
Non-Regression	180 (100 %)	141 (100 %)	306 (97.45 %)	627 (98.74 %)
Regression	0	0	8 (2.55 %)	8 (1.26 %)
Total	180 (28.35 %)	141 (22.2 %)	314 (49.44 %)	635 (100 %)
c	Biopsy—cone intervals according to Trimble et al. [9, 16]
Follow-up	<15 weeks		≥15 weeks	Total
Non-Regression	504 (99.21 %)		123 (96.85 %)	627 (98.74 %)
Regression	4 (0.79 %)		4 (3.15 %)	8 (1.26 %)
Total	508 (80.0 %)		127 (20.0 %)	635 (100 %)

a) three groups each representing a 33 % percentile of the time intervals of this study. 6 of 8 regression cases were observed in the group with intervals longer than 12 weeks, representing 2.9 % in this subgroup. b) Time intervals were chosen exactly as published by Munk et. al. to enable a direct comparison. All regression cases occurred in the longest interval group. The regression rate in this subgroup was lower than in any of the intervals investigated in the study of Munk et al. c) An analysis of only those cases showing an interval of 15 weeks or longer makes it possible to compare the regression rates with the data of Trimble et. al. [9, 16]. Our study found 3.15 % of regression among 127 cases evaluated in this subgroup

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