Skip to main content

Table 2 Study schedule

From: Improving the radical cure of vivax malaria (IMPROV): a study protocol for a multicentre randomised, placebo-controlled comparison of short and long course primaquine regimens

  Day Week Month       Rec Age > 60 m Age 12–60 m Age 6–< 12 m
  0 1 2 3 4 5 6 7 8 9 10 11 12 13 14a 17a 3 4 5 6 7 8 3 4 5 6 7 8 9 10 11 12   vol freq total vol freq total vol freq total
History of fever, current axillary temperature X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X          
Full medical history, vital sign, physical examination X                                          
MUAC & weight X                       X    X    X    X X          
Ask about any concomitant medication X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X          
Symptom checklist X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X          
Asses for any indication for study withdrawal   X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X          
Interviews to asses cost-of-illness X              X X                   X          
Urine pregnancy test X                                 X          
Masimo puls-oximeter-main study X X X X     X       X                             
Masimo puls-oximeter-G6PDd arm X X X X     X        X                            
Drug treatment                                           
 Standard schizontocidal theraphy X X X                               X          
 PQ-main study X X X X X X X X X X X X X X                    X          
 PQ-G6PDd arm X        X        X   X X X X X             X          
Capillary sample-microtainer up to 400 μL                                   0.4 26 10.4 0.4 26 10.4 0.4 26 10.4
 G6PD flourescent spottestb X                                          
 G6PD rapid test X                                          
 Parasite microscopyb X X X (X) (X) (X) (X) (X)          X X X X X X X X X X X X X X X X X          
 Rapid diagnostic test for malariab X                                          
 Haemoglobin HemoCueb-main study X    X     X       X    X X X X X X X X X X X X X X X X X          
 Haemoglobin HemoCueb-G6PDd arm X    X     X    X     X X X X X X X X X X X X X X X X X X X          
 Serology X                  X     X X    X    X    X X          
 Parasite genotype X                                 X          
EDTA venous samplec                                           
 From D0 EDTA: FBC, G6PD, HP, PG, serol, DC X                                  5 1 5 2 1 2 0.5 1 0.5
 From D7 & 13: FBC, DC         X      X X                     5 2 10 2 2 4 0.5 2 1
 EDTA Month 6: FBC, G6PD, pPCR, Serol                           X         5 1 5 2 1 2 0.5 1 0.5
 EDTA each recurrence: FBC PG, Serol, DC                                  X 5 2 10 2 2 4 0.5 2 1
Total blood volumes-2 malaria recurrence                                     40.4    22.4    13.4
Total blood volumes-no recurrence malaria                                     30.4    18.4    12.4
  1. aG6PDd arm only
  2. bin some centres these tests are routine & do not need to be repeated
  3. cif a venous sample cannot be obtained, obtain a capillary sample into a Microtainer