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Table 2 Univariate and multivariate analysis of survived and expired patients within 1 year and beyond 1 year

From: Outcome of patients on second line antiretroviral therapy under programmatic condition in India

  Within 1 year 1-5 year
Characteristics Uni-variate p- value Multi-variate p- value Uni-variate p-value Multi-variate p-value
HR (95 % CI) HR (95 % CI) HR (95 % CI) HR (95 % CI)
Age (years)
 >40 1.718 (0.712-4.145) 0.229    2.508 (0.879-7.154) 0.086   
 ≤40 1     1    
Sex
 Male 2.059 (0.480-8.839) 0.331    0.508 (0.158-1.630) 0.255   
 Female 1     1    
WHO Stage 1st line
 III + IV 2.616 (1.111-6.162) 0.028 0.710 (0.202-2.499) 0.594 1.956 (0.677-5.652) 0.215   
 I + II 1   1   1    
Tuberculosis 1st line
 Yes 1.218 (0.513-2.891) 0.654    1.001 (0.346-2.894) 0.998   
 No 1     1    
Adherence 1st line
 <95 % 1.115 (0.433-2.874) 0.822    5.673 (1.778-18.094) 0.003 5.226 (1.587-17.210) 0.007
 >95 % 1     1   1  
Weight (Kg) 1st line
 ≤45 0.867 (0.350-2.149) 0.759    2.407 (0.826-7.013) 0.107   
 >45 1     1    
CD4 count 1st line (/μL)
 <200 4.989 (0.670-37.178) 0.117    28.304 (0.085-924.0) 0.259   
 >200 1     1    
Duration of Immunological failure (months)
 >12 3.262 (1.182-11.123) 0.024 4.218 (1.146-15.519) 0.030 2.684 (0.824-8.745) 0.101   
 < 12 1   1   1    
Clinical failure
 Yes 2.721 (1.098-6.743) 0.031 1.056 (0.240-4.645) 0.943 0.640 (0.143-2.869) 0.560)   
 No 1   1   1    
CD4 count less than baseline
 Yes 3.579 (1.204-10.638) 0.022 4.111 (1.050-16.096) 0.042 2.120 (0.709-6.343) 0.179 3.328 (1.031-10.742) 0.044
 No 1   1   1   1  
50 % fall from peak CD4 count
 Yes 0.448 (0.174-1.154) 0.096    25.70 (0.038-1719.0) 0.328   
 No 1     1    
CD4 count < 100/μL
 Yes 2.100 (0.815-5.413) 0.125    3.038 (0.847-10.895) 0.088   
 No 1     1    
CD4 count 2nd line (/μL)
 <200 0.644 (0.150-2.765) 0.554    22.856 (0.003-1692.0) 0.491   
 >200 1     1    
WHO Stage 2nd line
 III + IV 15.854 (4.666-53.872) <0.001 11.871 (2.695-52.296) 0.001 1.446 (0.484-4.318) 0.509   
 I + II 1   1   1    
Weight (Kg) 2nd line
 ≤45 6.491 (1.512-27.877) 0.012 15.777 (1.734-143.535) 0.014 1.089 (0.363-3.269) 0.879   
 >45 1   1   1    
Viral Load 2nd Line (copies/ml)
 >177000 2.042 (0.824-5.061) 0.123    0.790 (0.274-2.279) 0.662   
 ≤177000 1     1    
Tuberculosis 2nd line
 Yes 4.219 (1.791-9.939) 0.001 2.336 (0.752-7.256) 0.142 0.854 (0.190-3.837) 0.837   
 No 1   1   1    
Adherence 2nd line
 <95 % 1.483 (0.575-3.821) 0.415    14.682 (4.093-52.660) <0.001 15.838 (4.274-58.685) <0.001
 >95 % 1     1   1