Characteristic | Daptomycin (n = 118) | Vancomycin (n = 106) |
---|---|---|
Demographics | ||
Male, n (%) | 64 (54.2) | 57 (53.8) |
Age, y, mean (SD) | 47.2 (15.2) | 50.0 (13.5) |
Weight, kg, mean (SD) | 97.1 (29.8) | 97.4 (30.4) |
BMI, mean (SD) | 33.2 (10.3) | 34.2 (11.7) |
Clinical characteristics | ||
Hospitalizations in preceding year, n (%) | 61 (51.7) | 49 (46.2) |
Patients with cSSSI in preceding 6 months, n (%) | 36 (30.5) | 37 (34.9) |
Charlson comorbidity score, mean (SD) | 1.1 (1.6) | 1.1 (1.3) |
Patients with diabetes, n (%) | 34 (28.8) | 37 (34.9) |
SIRS symptoms, n (%) | ||
Temperature > 38 °C or > 100.4 °F | 19 (16.1) | 12 (11.3) |
Heart rate > 90 beats/minute | 54 (45.8) | 43 (40.6) |
Tachypnea (> 20 breaths/minute) | 12 (10.2) | 6 (5.7) |
Blood pressure < 90/50 mmHg | 5 (4.2) | 1 (0.9) |
WBC count > 12 × 109/L | 61 (51.7) | 41 (38.7) |
Blood urea nitrogen > 8.9 mmol/L | 12 (10.2) | 6 (5.7) |
Creatinine > 132.6 μmol/L | 12 (10.2) | 9 (8.5) |
Patient-reported pain score, mean (SD) | 6.6 (3.0) | 6.9 (3.2) |
Vancomycin use at enrollment or within 48 h before randomization, n (%) | 65 (55.1) | 50 (47.1) |
Baseline blood culture, n (%) | 82 (69.5) | 76 (71.7) |
Gram-negative infection, n (%)a | 11 (16.7) | 7 (10.8) |
cSSSI diagnosis, n (%) | ||
Complicated cellulitisb | 81 (68.6) | 65 (61.3) |
Major cutaneous abscess | 45 (38.1) | 46 (43.4) |
Wound infection | 18 (15.3) | 16 (15.1) |
Erysipelas | 0 (0) | 0 (0) |
Diabetic ulcer | 2 (1.7) | 5 (4.7) |
Nondiabetic ulcer (stasis ulcer/decubitus ulcer) | 2 (1.7) | 3 (2.8) |
Bite wound | 1 (0.9) | 1 (0.9) |
Burn wound | 0 (0) | 0 (0) |
Otherc | 2 (1.7) | 3 (2.8) |