|
Demographics
|
|
Male, n (%)
|
64 (54.2)
|
57 (53.8)
|
|
Age, y, mean (SD)
|
47.2 (15.2)
|
50.0 (13.5)
|
|
Weight, kg, mean (SD)
|
97.1 (29.8)
|
97.4 (30.4)
|
|
BMI, mean (SD)
|
33.2 (10.3)
|
34.2 (11.7)
|
|
Clinical characteristics
|
|
Hospitalizations in preceding year, n (%)
|
61 (51.7)
|
49 (46.2)
|
|
Patients with cSSSI in preceding 6 months, n (%)
|
36 (30.5)
|
37 (34.9)
|
|
Charlson comorbidity score, mean (SD)
|
1.1 (1.6)
|
1.1 (1.3)
|
|
Patients with diabetes, n (%)
|
34 (28.8)
|
37 (34.9)
|
|
SIRS symptoms, n (%)
| | |
|
Temperature > 38 °C or > 100.4 °F
|
19 (16.1)
|
12 (11.3)
|
|
Heart rate > 90 beats/minute
|
54 (45.8)
|
43 (40.6)
|
|
Tachypnea (> 20 breaths/minute)
|
12 (10.2)
|
6 (5.7)
|
|
Blood pressure < 90/50 mmHg
|
5 (4.2)
|
1 (0.9)
|
|
WBC count > 12 × 109/L
|
61 (51.7)
|
41 (38.7)
|
|
Blood urea nitrogen > 8.9 mmol/L
|
12 (10.2)
|
6 (5.7)
|
|
Creatinine > 132.6 μmol/L
|
12 (10.2)
|
9 (8.5)
|
|
Patient-reported pain score, mean (SD)
|
6.6 (3.0)
|
6.9 (3.2)
|
|
Vancomycin use at enrollment or within 48 h before randomization, n (%)
|
65 (55.1)
|
50 (47.1)
|
|
Baseline blood culture, n (%)
|
82 (69.5)
|
76 (71.7)
|
|
Gram-negative infection, n (%)a
|
11 (16.7)
|
7 (10.8)
|
|
cSSSI diagnosis, n (%)
| | |
|
Complicated cellulitisb
|
81 (68.6)
|
65 (61.3)
|
|
Major cutaneous abscess
|
45 (38.1)
|
46 (43.4)
|
|
Wound infection
|
18 (15.3)
|
16 (15.1)
|
|
Erysipelas
|
0 (0)
|
0 (0)
|
|
Diabetic ulcer
|
2 (1.7)
|
5 (4.7)
|
|
Nondiabetic ulcer (stasis ulcer/decubitus ulcer)
|
2 (1.7)
|
3 (2.8)
|
|
Bite wound
|
1 (0.9)
|
1 (0.9)
|
|
Burn wound
|
0 (0)
|
0 (0)
|
|
Otherc
|
2 (1.7)
|
3 (2.8)
|
