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Table 2 Accuracy metrics (point estimates and 95%CIs) of three rapid tests compared to results obtained by enzyme immunoassay ETI-MAK-4® in serum samples according to the characteristics of the study population

From: Evaluating HBsAg rapid test performance for different biological samples from low and high infection rate settings & populations

Profile/Manufacturer (n) TP FN TN FP Sensitivity Specificity PPV NPV K
Group I
 Vikia HBsAg ®(371) 160 7 204 0 95.81 % (91.54–98.30) 100.00 % (98.21–100.00) 100.00 % (97.72–100.00) 96.68 % (93.30–98.65) 96.17 % (93.36–98,98)
 Imuno-rápido HBsAg® (371) 157 10 203 1 94.01 % (89.27–97.09) 99.51 % (97.30–99.99) 99.37 % (96.53–99.98) 95.31 % (91.53–97.72) 93.98 % (90.48–97.48)
 HBsAg Teste rápido® (371) 156 11 203 1 93.41 % (88.53–96.67) 99.51 % (97.30–99.99) 99.36 % (96.51–99.98) 94.86 % (90.99–97.41) 93.43 % (89.77–97.09)
Group II
 Vikia HBsAg ®(881) 3 2 875 1 60.00 % (14.67–94.73) 99.89 % (99.37–100.00) 75.00 % (19.42–99.37) 99.77 % (99.18–99.97) 66.50 % (28.65–100.00)
 Imuno-rápido HBsAg® (881) 3 2 852 24 60.00 % (14.67–94.73) 97.26 % (95.94–98.24) 11.11 % (23.55–29.18) 99.77 % (99.16–99,97) 17.96 % (0.00–49.02)
 HBsAg Teste rápido® (881) 3 2 857 19 60.00 % (14.67–94.73) 97.83 % (96.63–98.69) 13.64 % (29.04–34.94) 99.77 % (99,16–99.97) 21.50 % (0.00–54.67)
Group III
 Vikia HBsAg ®(251) 4 2 245 0 66.67 % (22.27–95.67) 100.00 % (98.51–100.00) 100.00 % (39.76–100.00) 99.19 % (97.11–99.90) 79.61 % (51.46–100.00)
 Imuno-rápido HBsAg® (251) 4 2 244 1 66.67 % (22.27–95.67) 99.59 % (97.75–99.99) 80.00 % (28.35–99.49) 99.19 % (97.11–99.90) 72.12 % (40.76–100.00)
 HBsAg Teste rápido® (251) 4 2 243 2 66.67 % (22.27–95.67) 99.18 % (97.08–99.90) 66.67 % (22.27–95.67) 99.19 % (97.11–99.90) 65.85 % (32.65–99.05)
Overall
 Vikia HBsAg ® (1503) 167 11 1324 1 93.82 % (89.21–96.87) 99.92 % (99.58–100.00) 99.40 % (96.73–99.98) 99.18 % (98.53–99.59) 96.08 % (93.87–98.29)
 Imuno-rápido HBsAg® (1503) 164 14 1299 26 92.13 % (87.14–95.63) 98.04 % (97.14–98.71) 86.32 % (80.57–90.86) 98.93 % (98.21–99.42) 87.62 % (83.83–91.41)
 HBsAg Teste rápido® (1503) 163 15 1303 22 91.57 % (86.50–95.21) 98.34 % (97.49–98.96) 88.11 % (82.57–92.39) 98.86 % (98.13–99.36) 88.41 % (84.72–92.1)
  1. Legends: TP True positive, FN False negative, TN True negative, FP False positive, PPV Positive Predictive Value, NPV Negative Predictive Value, k kappa statistics, n number of samples, CI confidence interval