Table 5 Sensitivity, Specificity, PPV and NPV for typhoid fever of ELISA and Widal test in different cut off titers
Test | Titer | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
95 % CI | 95 % CI | 95 % CI | 95 % CI | ||
IgM | ≥1:200 | 95.50 % | 94.69 % | 77.66 % | 99.09 % |
91.87 % to 97.82 % | 93.23 % to 95.92 % | 72.24 % to 82.46 % | 98.33 % to 99.56 % | ||
≥1:400 | 81.23 % | 98.29 % | 91.77 % | 95.70 % | |
75.95 % to 85.78 % | 97.34 % to 98.97 % | 87.45 % to 94.98 % | 94.36 % to 96.80 % | ||
≥1:800 | 61.97 % | 96.48 % | 78.38 % | 92.50 % | |
55.41 % to 68.21 % | 95.24 % to 97.48 % | 71.74 % to 84.08 % | 90.85 % to 93.93 % | ||
≥1:1600 | 51.89 % | 93.79 % | 60.44 % | 91.42 % | |
44.94 % to 58.78 % | 92.24 % to 95.11 % | 52.94 % to 67.60 % | 89.68 % to 92.95 % | ||
≥1:3200 | 47.44 % | 92.73 % | 54.84 % | 90.46 % | |
40.61 % to 54.34 % | 91.08 % to 94.16 % | 47.39 % to 62.13 % | 88.65 % to 92.08 % | ||
IgG | ≥1:200 | 96.85 % | 94.95 % | 78.75 % | 99.36 % |
93.61 % to 98.72 % | 93.52 % to 96.14 % | 73.42 % to 83.45 % | 98.69 % to 99.74 % | ||
≥1:400 | 85.95 % | 98.76 % | 93.69 %** | 97.04 % | |
80.92 % to 90.07 % | 97.93 % to 99.32 % | 89.65 % to 96.51 % | 95.89 % to 97.94 % | ||
≥1:800 | 62.61 % | 97.09 % | 81.87 % | 92.51 % | |
56.12 % to 68.77 % | 95.93 % to 97.99 % | 75.49 % to 87.18 % | 90.87 % to 93.95 % | ||
≥1:1600 | 51.89 % | 94.48 % | 63.22 % | 91.48 % | |
44.94 % to 58.78 % | 93.00 % to 95.72 % | 55.59 % to 70.39 % | 89.75 % to 93.00 % | ||
≥1:3200 | 47.44 % | 92.73 % | 54.84 % | 90.46 % | |
40.61 % to 54.34 % | 91.08 % to 94.16 % | 47.39 % to 62.13 % | 88.65 % to 92.08 % | ||
TO | ≥1:100 | 90.32 % | 52.41 % | 44.22 % | 92.12 % |
87.25 % to 92.47 % | 49.10 % to 53.91 % | 41.18 % to 50.73 % | 88.71 % to 94.83 % | ||
≥1:200 | 80.95 % | 51.77 % | 23.29 % | 93.76 % | |
74.98 % to 86.03 % | 48.85 % to 54.68 % | 20.27 % to 26.53 % | 91.60 % to 95.50 % | ||
≥1:400 | 84.09 % | 52.65 % | 25.34 % | 94.54 % | |
78.58 % to 88.66 % | 49.72 % to 55.57 % | 22.22 % to 28.66 % | 92.49 % to 96.17 % | ||
TH | ≥1:100 | 80.32 % | 53.22 % | 48.40 % | 90.87 % |
75.28 % to 85.91 % | 46.42 % to 55.36 % | 42.83 % to 50.27 % | 87.14 % to 92.84 % | ||
≥1:200 | 72.23 % | 58.33 % | 38.13 % | 89.37 % | |
68.24 % to 79.72 % | 52.93 % to 64.22 % | 31.23 % to 43.10 % | 83.11 % to 94.07 % | ||
≥1:400 | 62.47 % | 55.23 % | 39.48 % | 90.62 % | |
59.23 % to 66.82 % | 47.21 % to 59.99 % | 31.34 % to 45.83 % | 86.92 % to 95.27 % |