Table 1 Characteristics of 5 kidney transplant recipients with invasive or disseminated Neoscytalidium infection
From: Invasive cutaneous Neoscytalidium infections in renal transplant recipients: a series of five cases
Patient | Age | Sex | Year of diagnosis | Origin | Time from transplantation (months) | Immunosuppressive regimensb | Type/Localization | Presence of skin appendage involvement | Identification | Treatment | Outcome | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
First line | Second line | |||||||||||
1 | 53 | Male | 2001 | French Guyana | 3 | Mycophenolic acid (250 mg), tacrolimus (6 mg) and prednisone (20 mg) | Deep cutaneous/right leg | Nail | Neoscytalidium sp | Itraconazole + surgical resection | Local amphotericin B added | Surgery first failed, then oral and local treatment succeeded after more than 4 months |
2 | 64 | Female | 2002 | Ivory Coast | 134 | Cyclosporine (100 mg) and prednisolone (10 mg) | Deep cutaneous/left foot | Right foot (sole and nail), | Neoscytalidium hyalinum | General (rapidly discontinued) and local terbinafine, 1 year | Clinical success, but samples positive 1 year after treatment | |
3 | 52 | Male | 2007 | Mauritania | 105 | Mycophenolic acid (1500 mg), tacrolimus (3 mg) and prednisone (10 mg). | Deep cutaneous/right ankle | Neoscytalidium dimidiatum | Surgical resection only | Surgery succeeded | ||
4 | 59 | Male | 2011 | Cameroun | 8 | Mycophenolic acid (1000 mg), tacrolimus (30 mg), and prednisone (7.5 mg) | Disseminated: right leg and foot | Nail sample (2006) | Neoscytalidium dimidiatum | Voriconazole 200 mg bid | Local ketoconazole added | Resolved in 3 months, treatment 5 months. |
5 | 49 | Male | 2011 | Congo Brazzaville | 15 | Azathioprine (50 mg), tacrolimus (20 mg) and prednisone (15 mg) | Disseminated: cutaneous/sinal and pulmonary | Neoscytalidium dimidiatum | Voriconazole 200 mg bid | Resolved in 1 year | ||