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Table 1 Characteristics of 5 kidney transplant recipients with invasive or disseminated Neoscytalidium infection

From: Invasive cutaneous Neoscytalidium infections in renal transplant recipients: a series of five cases

Patient Age Sex Year of diagnosis Origin Time from transplantation (months) Immunosuppressive regimensb Type/Localization Presence of skin appendage involvement Identification Treatment Outcome
           First line Second line  
1 53 Male 2001 French Guyana 3 Mycophenolic acid (250 mg), tacrolimus (6 mg) and prednisone (20 mg) Deep cutaneous/right leg Nail Neoscytalidium sp Itraconazole + surgical resection Local amphotericin B added Surgery first failed, then oral and local treatment succeeded after more than 4 months
2 64 Female 2002 Ivory Coast 134 Cyclosporine (100 mg) and prednisolone (10 mg) Deep cutaneous/left foot Right foot (sole and nail), Neoscytalidium hyalinum General (rapidly discontinued) and local terbinafine, 1 year   Clinical success, but samples positive 1 year after treatment
3 52 Male 2007 Mauritania 105 Mycophenolic acid (1500 mg), tacrolimus (3 mg) and prednisone (10 mg). Deep cutaneous/right ankle   Neoscytalidium dimidiatum Surgical resection only   Surgery succeeded
4 59 Male 2011 Cameroun 8 Mycophenolic acid (1000 mg), tacrolimus (30 mg), and prednisone (7.5 mg) Disseminated: right leg and foot Nail sample (2006) Neoscytalidium dimidiatum Voriconazole 200 mg bid Local ketoconazole added Resolved in 3 months, treatment 5 months.
5 49 Male 2011 Congo Brazzaville 15 Azathioprine (50 mg), tacrolimus (20 mg) and prednisone (15 mg) Disseminated: cutaneous/sinal and pulmonary   Neoscytalidium dimidiatum Voriconazole 200 mg bid   Resolved in 1 year
  1. aFor patients who underwent 2 transplantations, the time is the interval between diagnosis and the date of the second transplantation
  2. bImmunosuppressive regimen at the time of diagnosis; dosages are per day