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Table 6 Clinical, parasitological and other characteristics of patients with falls in haematocrit ≥5 and <5 units on day 21, 28 or both following treatment with artesunate-amodiaquine or artemether-lumefantrine

From: Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children

  ≥5 units fall in haematocrita <5 units fall in haematocrit P value
Number 51 38  
M/F 27/24 22/16 0.72
 Age (year)
 Mean (sd) 6.6 (3.1) 6.8 (3.3) 0.73
 Range 0.7 – 13.0 2.5–14  
 No. < 5 years 19 18 0.46
Duration of illness (days)
 Mean (sd) 2.6 (1) 2.6 (0.9) 0.96
 Range 1–5 1–5  
Weight (kg)
 Mean (sd) 18.8 (6.7) 19.1 (6.2) 0.82
 Range 7–37 11–36  
Haematocrit (%)
 Mean (sd) 35.9 (3.3) 33.1 (3) < 0.0001
 Range 29–42 24–38  
Temperature (°C)
 Mean (sd) 38.2 (1.1) 38.5 (1.3) 0.26
 Range 35.0–40.4 36.0–40.9  
No. with temperature
 >37.4 °C 39 31 0.68
 >40.0 °C 3 5 0.25
Parasitaemia(/μL)
 Geometric mean 72,208 44,751 0.026
 Range 3,529–501,946 3,749–281,538  
No. with parasitaemia
 > 100,000/μL 22 6 0.003
 > 250,000/μl 5 2 0.42
PCT (day) (sd) 1.1 (0.2) 1.2 (0.4) 0.14
No. with parasitaemia on day 1 3 6 0.15
Median dose (mg/kg)
 Artesunate (range) 12.5 (5–40) [n = 43] 11.1 (4.7–18) [n = 24] 0.12
 Amodiaquine (range) 33.5 (15.3–76.5) [n = 43] 30.9 (14.3–55.1) [n = 24] 0.18
 Artemether (range) 10.7 (9.2–16) [n = 8] 12.4 (7.1–16) [n = 11] 0.78
 Lumefantrine (range) 64.3 (55.4–96) [n = 8] 68.6 (42.4–90) [n = 11] 0.78
  1. aSix of the seven children with late fall in haematocrit belong to this group (see also Table 4)