Table 6 Clinical, parasitological and other characteristics of patients with falls in haematocrit ≥5 and <5 units on day 21, 28 or both following treatment with artesunate-amodiaquine or artemether-lumefantrine

Number

51

38

M/F

27/24

22/16

0.72

 Mean (sd)

6.6 (3.1)

6.8 (3.3)

0.73

 Range

0.7 – 13.0

2.5–14

 No. < 5 years

19

18

0.46

 Mean (sd)

2.6 (1)

2.6 (0.9)

0.96

 Range

1–5

1–5

 Mean (sd)

18.8 (6.7)

19.1 (6.2)

0.82

 Range

7–37

11–36

 Mean (sd)

35.9 (3.3)

33.1 (3)

< 0.0001

 Range

29–42

24–38

 Mean (sd)

38.2 (1.1)

38.5 (1.3)

0.26

 Range

35.0–40.4

36.0–40.9

 >37.4 °C

39

31

0.68

 >40.0 °C

3

5

0.25

 Geometric mean

72,208

44,751

0.026

 Range

3,529–501,946

3,749–281,538

 > 100,000/μL

22

6

0.003

 > 250,000/μl

5

2

0.42

PCT (day) (sd)

1.1 (0.2)

1.2 (0.4)

0.14

No. with parasitaemia on day 1

3

6

0.15

 Artesunate (range)

12.5 (5–40) [n = 43]

11.1 (4.7–18) [n = 24]

0.12

 Amodiaquine (range)

33.5 (15.3–76.5) [n = 43]

30.9 (14.3–55.1) [n = 24]

0.18

 Artemether (range)

10.7 (9.2–16) [n = 8]

12.4 (7.1–16) [n = 11]

0.78

 Lumefantrine (range)

64.3 (55.4–96) [n = 8]

68.6 (42.4–90) [n = 11]

0.78