Skip to main content

Advertisement

Table 4 Features of patients with late fall in haematocrit below 30 % (Pattern 3)

From: Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children

Patient (gender, age) Year of enrolment Parasitaemia
(μL−1)
Enrolment HCT (%) Antimalarial treatment PCT
(day)
Nadir HCT(%)a (day) HCT on day 42 (%) Outcome
AnRT (day)
Total of mg/kg dose of AA Total of mg/kg dose of AL
Artesunate amodiaquine artemether lumefantrine
13 (F, 4.9y) 2010 357,397 40 AA 1 27 (21) 30 14 11.5 31.2 NA NA
20 (M, 4.9y) 2010 197,308 30 AL 1 20 (21) 40 14 NA NA 9.2 55.4
28 (F, 8y) 2010 157,200 37 AA 1 27 (14) 33 14 17.5 30.0 NA NA
45 (M, 5.4y) 2009 34,000 30 AL 2 28 (21) 32 21 NA NA 15 90
93 (F, 7.8y) 2009 35,593 34 AA 1 23 (21) 31 21 7.5 23.0 NA NA
167 (M, 6y) 2009 14,792 34 AA 1 29 (21) 33 14 16.7 51.0 NA NA
200 (M, 2y) 2009 181,000 34 AA 1 28 (14) 33 14 10.5 42.6 NA NA
  1. aPercentage fall in haemaocrit compared to pre-treatment values in descending order of cases are: 40 %, 33 %, 33 %, 32 %,27 %, 18 %, and 15 %, respectively
  2. NA = Not Applicable; AA = artesunate-amodiaquine; AL = artemether-lumefantrine; HCT = Haematocrit, PCT = Parasite clearance time
  3. AnRT = anaemia recovery time