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Table 4 Features of patients with late fall in haematocrit below 30 % (Pattern 3)

From: Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children

Patient (gender, age)

Year of enrolment

Parasitaemia

(μL−1)

Enrolment HCT (%)

Antimalarial treatment

PCT

(day)

Nadir HCT(%)a (day)

HCT on day 42 (%)

Outcome

AnRT (day)

Total of mg/kg dose of AA

Total of mg/kg dose of AL

Artesunate

amodiaquine

artemether

lumefantrine

13 (F, 4.9y)

2010

357,397

40

AA

1

27 (21)

30

14

11.5

31.2

NA

NA

20 (M, 4.9y)

2010

197,308

30

AL

1

20 (21)

40

14

NA

NA

9.2

55.4

28 (F, 8y)

2010

157,200

37

AA

1

27 (14)

33

14

17.5

30.0

NA

NA

45 (M, 5.4y)

2009

34,000

30

AL

2

28 (21)

32

21

NA

NA

15

90

93 (F, 7.8y)

2009

35,593

34

AA

1

23 (21)

31

21

7.5

23.0

NA

NA

167 (M, 6y)

2009

14,792

34

AA

1

29 (21)

33

14

16.7

51.0

NA

NA

200 (M, 2y)

2009

181,000

34

AA

1

28 (14)

33

14

10.5

42.6

NA

NA

  1. aPercentage fall in haemaocrit compared to pre-treatment values in descending order of cases are: 40 %, 33 %, 33 %, 32 %,27 %, 18 %, and 15 %, respectively
  2. NA = Not Applicable; AA = artesunate-amodiaquine; AL = artemether-lumefantrine; HCT = Haematocrit, PCT = Parasite clearance time
  3. AnRT = anaemia recovery time