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Table 3 Mean seasonal RSV-attributable burden of GP episodes, hospital admissions and deaths due to respiratory disease among adults by age group; United Kingdom 1995-2009

From: Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom

  GP episodes Hospitalisations Deaths
Age (years) Episodes/100,000 population (range) N % of events attributable to RSV** RSV:influenza ratio† Hospitalisations/100,000 population (range) N % of events attributable to RSV** RSV:influenza ratio† Deaths/100,000 population (range) N % of events attributable to RSV** RSV:influenza ratio†
Respiratory disease
18-49 677 (443–850) 176534 3.3 0.6:1 4 (3–5) 1033 1.4 0.3:1 1 (0–1) 144 4.2 0.8:1
50-64 1325 (928–1542) 136469 6.1 1.1:1 30 (22–36) 3067 5.2 0.8:1 6 (5–7) 656 5.9 0.9:1
65-74 1742 (1259–2038) 86201 6.6 1.6:1 86 (62–101) 4236 5.8 0.8:1 29 (21–33) 1416 5.7 0.9:1
75+ 2175 (1554–2516) 88043 7.5 1.6:1 234 (180–291) 9463 6.8 0.9:1 155 (108–213) 6266 5.9 0.7:1
Acute upper respiratory disease
18-49 394 (261–489) 102728 3.9 0.8:1 - - - - - - - -
50-64 590 (430–696) 60757 7.8 1.7:1 - - - - - - - -
65-74 557 (433–701) 27580 8.4 2.5:1 - - - - - - - -
75+ 528 (407–659) 21372 10.1 2.4:1 - - - - - - - -
Pneumonia and Influenza
18-49 51 (17–97) 13217 5.8 0.1:1 2 (2–3) 615 5.8 0.6:1 0 (0–1) 103 5.9 0.8:1
50-64 88 (40–145) 9031 10.4 0.2:1 7 (5–9) 736 7.2 1.0:1 4 (3–5) 391 7.3 0.9:1
65-74 116 (66–167) 5755 13.6 0.4:1 20 (15–26) 987 7.3 1.0:1 17 (12–20) 821 6.7 0.8:1
75+ 196 (112–279) 7944 11.2 0.6:1 80 (51–109) 3238 7.7 1.0:1 121 (86–164) 4884 7.1 0.7:1
Bronchitis/ Bronchiolitis
18-49 229 (163–264) 59799 6.0 0.7:1 2 (1–2) 444 4.3 0.5:1 0 (0–0) 4 6.2 0.6:1
50-64 653 (458–759) 67269 9.7 1.2:1 7 (5–9) 764 8.3 0.7:1 0 (0–1) 43 17.2 1.0:1
65-74 1088 (776–1257) 53839 11.0 1.8:1 19 (14–22) 952 9.1 0.7:1 1 (1–2) 66 12.6 1.0:1
75+ 1594 (1147–1858) 64540 12.3 1.8:1 75 (56–91) 3037 10.6 0.8:1 5 (3–7) 204 10.2 0.8:1
COPD
18-49 23 (14–31) 6034 1.2 1.7:1 0 (0–0) 0 0.0 0:1 0 (0–0) 15 3.8 0.7:1
50-64 77 (49–100) 7943 2.7 2.2:1 14 (10–17) 1484 5.8 0.8:1 3 (2–4) 296 8.9 1.1:1
65-74 136 (72–206) 6734 2.7 2.9:1 45 (32–52) 2229 6.5 0.9:1 14 (9–17) 685 7.5 0.9:1
75+ 82 (44–121) 3300 1.7 1.4:1 75 (55–88) 3052 7.4 1.2:1 36 (27–48) 1456 6.5 0.8:1
Cardiorespiratory
18-49 - -   - 1 (1–3) 376 0.4 0.1:1 1 (1–1) 213 2.8 1:1
50-64 - -   - 18 (12–22) 1837 1.3 0.5:1 8 (6–10) 859 3.4 0.9:1
65-74 - -   - 56 (39–67) 2780 1.6 0.6:1 37 (25–44) 1826 3.5 0.9:1
75+ - -   - 174 (126–204) 7042 2.3 0.7:1 198 (155–259) 8028 4.1 0.8:1
Antibiotic prescriptions
18-49 610 (442–715) 159223 2.6 0.7:1 - - - - - - - -
50-64 1449 (1081–1750) 149229 5.3 1.4:1 - - - - - - - -
65-74 1999 (1556–2520) 98921 6.0 2:1 - - - - - - - -
75+ 2261 (1809–2938) 91535 6.3 2.1:1 - - - - - - - -
  1. N = Seasonal number of specified RSV-attributable events in the UK
  2. Proportion = per 100,000 population
  3. Range = range of estimates per season
  4. GP = general practice, COPD = chronic obstructive pulmonary disease
  5. *Outcomes refer to the ‘Primary’ cause for hospitalisation for HES, or as the ‘Any mention’ cause of death for ONS. For the GPRD data there is no ordered listing or ranking of diagnostic codes
  6. **% of RSV-attributable events among all events due to outcome
  7. † ratio of proportions/100,000 RSV/[influenza A + B]