Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom

Table 1 Outcomes: GP episodes (CPRD), hospitalisations (HES), deaths (ONS)

Outcome	ICD10 codes	GP (CPRD)*	Hospitalisation (HES)***	Deaths (ONS)
Respiratory outcomes
Respiratory disease	J00-99	X**	X	X
Cardiorespiratory disease	I00-99,J00-99		X	X
Acute upper resp disease	J00, J02-06	X
Pneumonia & influenza	J09-18	X	X	X
Bronchitis/Bronchiolitis	J20-22, J40	X	X	X
Chronic resp disease	J41-47	X	X	X
Drug prescriptions
Antibiotics (broad spectrum penicillins, macrolides, tetracyclines)^‡		X	-	-
Non-Respiratory control outcomes
Accidents	V00-99,X00-99,Y00-99		X
Urinary Tract Infection	N39	X	X	X
Risk group conditions
Chronic resp disease	J40-J47	X	X	X
Cardiovascular disorders	I00-I52 (except I01-04, I10, I30, I32-33, I40, I46, I49.1, I49.4)	X	X	X
Kidney disorders	N00-N29 (except N00, N10, N17, N20-23)	X	X	X
Diabetes	E10-E14	X	X	X
Immunosuppression	B20-24, O98.7, C00-C99, D37-D48, Z21	X	X	X
Liver disorders	K70-K77	X	X	X
Stroke	I60-I69	X	X	X
Central nervous system disorders	Q00-Q07, G10-G39, G45-46, G70-G99	X	X	X

CPRD does not provide any ranking of diagnostic codes. HES database outcomes listed as the primary discharge diagnosis were studied. ONS database outcomes listed as any mention of the outcome as the cause of death were studied
Risk group defined according to the chronic conditions indicative of risk for severe influenza as per UK recommendation for influenza vaccination
*Any CPRD GP episode, including office visits, home visits, telephone consults and other types, for subjects with subjects registered with research quality data in CPRD. CPRD diagnostic data are coded using READ codes. The list of appropriate Read codes for each definition was generated in consultation with a UK expert (Douglas Fleming) and GSK CPRD expert (David Webb). CPRD diagnostic, antibiotic and risk codes are given in Additional file 1
**Respiratory disease was broadly defined to consider CPRD READ codes corresponding to all ICD-listed codes related to respiratory disease as well as READ codes corresponding to selected symptoms and diagnoses in the CPRD (see description of selection procedure in Methods): these included cough, breathing abnormalities, viral infections, sepsis and septicemia
***Only unscheduled, “emergency” hospitalisations were included
^‡antibiotics relevant to respiratory disease

ISSN: 1471-2334