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Table 2 Patient demographics, viral load, CD4 count, co-receptor tropism and transmission route for the most prevalent subtypes and CRF

From: Characteristics and spread to the native population of HIV-1 non-B subtypes in two European countries with high migration rate

  A (N = 74) C (N = 63) CRF_01AE (N = 66) CRF02_AG (N = 100) Other subtypes and CRF (N = 63) p
Total, N = 366 Count (%) p Count (%) p Count (%) p Count (%) p Count (%) p
Gender, N = 301            
  Male, N (%) 32 (50) NS 22 (38.6) NS 35 (56.5) 0.089 39 (43.3) NS 13 (46.4) NS NS
Age, N = 347            
  Median (IQR) 33 (27–40) NS 34 (27–40) NS 34 (27–44) NS 32(28–38) NS 33 (29–40) NS NS
CD4/μl, N = 362            
  Median (IQR) 351 (240–567) NS 310 (146–310) NS 335 (120–510) NS 335 (222–535) NS 293 (141–571) NS NS
Viral load, N = 363            
  Median log c/ml (IQR) 4.54 (3.85-5.25) NS 4.35 (3.72-4.86) NS 4.82 (4.22-5.28) 0.045 4.64 (3.88-5.10) NS 4.51 (3.82-5.00) NS NS
Tropisme G2P, N = 366            
  X4 (G2P 10 %), N(%) 16 (21.6) NS 7 (11.1) 0.014 30 (45.5) <0.001 17 (17.0) 0.097 14 (22.2) NS <0.001
  X4 (G2P 5,75 %), N(%) 8 (10.8) NS 3 (4.8) 0.014 24 (36.4) <0.001 9 (9.0) 0.057 10 (15.9) NS <0.001
Tropisme PSSM, N = 360            
  X4 (PSSM-B), N(%) 12 (16.9) NS 8 (12.7) 0.072 26 (40.0) <0.001 16 (16.3) NS 14 (22.2) NS 0.001
  X4 (PSSM-C), N(%)    16 (16,3) NS        
Tropisme Phenoseq, N = 277 8 (12.9) 0.021 19 (31.1) NS 13 (21.2) NS 26 (28.0) NS    NS
  X4, N(%)            
Transmission route            0.005
  Hetero, N (%) 44 (59.5) NS 37 (58.7) NS 42 (63.6) NS 57 (57.0) NS 39 (61.9) NS  
  MSM, N (%) 0 (0) 0.003 3 (4.8) NS 12 (18.2) 0.011 11 (11.0) NS 6 (9.5) NS  
  Other, N (%) 9 (12.2) 0.020 2 (3.2) NS 2 (3.0) NS 4 (4.0) NS 5 (7.9) NS  
  Unknown, N (%) 21 (28,4) NS 21 (33,3) NS 10 (15,2) 0,034 28 (28,0) NS 13 (20,6) NS  
Country of origin, N = 366            <0.001
  Europe-West, N (%) 12 (16.2) 0.008 15 (23.8) NS 31 (47.0) 0.001 22 (22.0) 0.053 27 (42.9) 0.016  
  Europe-East, N (%) 13 (17.6) <0.001 0 (0) NS 0 (0) 0.082 0 (0) 0.014 1 (2.4) NS  
  Africa-Nord/Middle East, N (%) 2 (2.7) NS 1 (1.6) NS 0 (0) NS 4 (4.0) NS 1 (1.6) NS  
  Africa-West, N (%) 10 (13.5) 0.016 1 (1.6) <0.004 2 (3.0) <0.001 58 (58.0) <0.001 20 (31.7) NS  
  Africa-Central, N (%) 26 (35.1) <0.001 19 (30.2) 0.001 1 (1.5) <0.001 7 (7.0) 0.003 7 (11.1) NS  
  Africa-East, N (%) 2 (2.7) NS 8 (12.7) 0.002 0 (0) 0.050 2 (2.2) NS 4 (6.3) NS  
  Africa-South, N (%) 2 (2.7) NS 11 (17.5) <0.001 0 (0) NS 0 (0) 0.023 0 (0) NS  
  Asia, N (%) 0 (0) 0.004 2 (3.2) NS 29 (43.9) <0.001 0 (0) <0.001 0 (0) 0.007  
  Latin America, N (%) 0 (0) NS 0 (0) NS 0 (0) NS 1 (1) NS 1 (1.6) NS  
  Unknown, N (%) 7 (9.5) NS 6 (9.5) NS 3 (4.5) NS 6 (6.0) NS 2 (3.2) NS  
  1. Subtype classification based on pol sequences
  2. Significance was set at ≤0,05; p-values ≤0,1 are shown; p-values of ≤0,05 are marked in bold; NS = not significant, p > 0,1