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Table 4 Summary of studies examining the incidence of and risk factors for recurrent SSTI in HIV-infected adults

From: Recurrent skin and soft tissue infections in HIV-infected patients during a 5-year period: incidence and risk factors in a retrospective cohort study

Study

Population

Methodology

Outcome

Recurrence rate

Risk factors for recurrence

Crum-Cianflone et al. [10]

31 subjects with initial MRSA SSTI

Retrospective, single center

Any recurrent SSTI

41 % (all SSTI)

Lower CD4 counta

21 % (MRSA SSTI)

Higher viral loadab

Lack of incision and drainageab

Positive nare culturea

Crum-Cianflone et al. [26]

379 subjects with initial SSTI

Prospective, multi-center

Any recurrent SSTI

31 %

No significant risk factor identified

Trend toward viral load and dermatologic condition predicting SSTI recurrence

Graber et al. [9]

62 subjects with initial MRSA SSTI

Retrospective, single center

Any recurrent SSTI

71 %

No significant risk factor identified

Vyas et al. [11]

63 individuals with initial MRSA SSTI

Retrospective, single center

Recurrent MRSA SSTI

27 %

Older agea

Lower CD4 count at initial SSTIab

Lower nadir CD4 counta

Higher peak viral loada

Prior AIDS defining illnessa

History of malignancya

IVDU*

Use of antibiotic other than minocyclineab

Hospital admissionab

Surgerya

Skiest et al. [12]

41 subjects with initial MRSA SSTI

Prospective, single center

Any recurrent SSTI

29.7 %

No significant risk factor identified

Present study

85 subjects with initial SSTI

Retrospective, single center

Any recurrent SSTI

35 % (raw)

Catheterab

Non-viral liver diseaseab

Non-African American raceab

Lymphedemaa

IVDUb

  1. aUnivariate analysis
  2. bMultivariate analysis