Skip to main content

Table 4 Summary of studies examining the incidence of and risk factors for recurrent SSTI in HIV-infected adults

From: Recurrent skin and soft tissue infections in HIV-infected patients during a 5-year period: incidence and risk factors in a retrospective cohort study

Study Population Methodology Outcome Recurrence rate Risk factors for recurrence
Crum-Cianflone et al. [10] 31 subjects with initial MRSA SSTI Retrospective, single center Any recurrent SSTI 41 % (all SSTI) Lower CD4 counta
21 % (MRSA SSTI) Higher viral loadab
Lack of incision and drainageab
Positive nare culturea
Crum-Cianflone et al. [26] 379 subjects with initial SSTI Prospective, multi-center Any recurrent SSTI 31 % No significant risk factor identified
Trend toward viral load and dermatologic condition predicting SSTI recurrence
Graber et al. [9] 62 subjects with initial MRSA SSTI Retrospective, single center Any recurrent SSTI 71 % No significant risk factor identified
Vyas et al. [11] 63 individuals with initial MRSA SSTI Retrospective, single center Recurrent MRSA SSTI 27 % Older agea
Lower CD4 count at initial SSTIab
Lower nadir CD4 counta
Higher peak viral loada
Prior AIDS defining illnessa
History of malignancya
IVDU*
Use of antibiotic other than minocyclineab
Hospital admissionab
Surgerya
Skiest et al. [12] 41 subjects with initial MRSA SSTI Prospective, single center Any recurrent SSTI 29.7 % No significant risk factor identified
Present study 85 subjects with initial SSTI Retrospective, single center Any recurrent SSTI 35 % (raw) Catheterab
Non-viral liver diseaseab
Non-African American raceab
Lymphedemaa
IVDUb
  1. aUnivariate analysis
  2. bMultivariate analysis