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Table 4 Predictors of mortality in HIV-positive adults on MDR-TB treatment at Sizwe Tropical Disease Hospital, Johannesburg

From: Treatment outcomes in multidrug resistant tuberculosis-human immunodeficiency virus Co-infected patients on anti-retroviral therapy at Sizwe Tropical Disease Hospital Johannesburg, South Africa

  aUnivariable Analysis bMultivariable Analysis
Factor OR (95 % CI) p-value OR (95 % CI) p-value
ART regimen     
 After 1.00   1.00  
 Prior 1.49 (1.06–2.09) 0.021* 1.65 (1.00–2.73) 0.050*
Age 1.01 (0.99–1.03) 0.481   
Sex     
 Female 1.00   1.00  
 Male 1.08 (0.78–1.49) 0.661 1.58 (0.94–2.66) 0.085
Site of TB     
 Pulmonary 1.00    
 Extra-Pulmonary + Pulmonary 1.40 (0.94–2.09) 0.098   
BMI categories (kg/m2)     
 Severely Underweight (<16) 4.61 (2.77–7.68) <0.001* 3.71 (1.89–7.29) <0.001*
 Underweight (≥16–18.49) 2.33 (1.49–3.65) <0.001* 2.35 (1.30–4.26) 0.005*
 Normal (≥18.5–24.99) 1.00   1.00  
 Overweight/ obese (25–29.99) 1.20 (0.57–2.51) 0.630 2.30 (0.92–5.71) 0.074
Co-trimoxazole Prophylaxis     
 No 1.00   1.00  
 Yes 1.33 (0.62–2.89) 0.464 1.30 (0.47–3.54) 0.613
CD4 Categories (mls/mm3)     
 <150 2.88 (1.62–5.14) <0.001* 1.56 (0.73–3.38) 0.243
 150–349 0.91 (0.48–1.72) 0.770 0.63 (0.28–1.42) 0.266
 ≥350 1.00   1.00  
Haemoglobin (g/dl) 0.76 (0.70–0.82) <0.001* 0.90 (0.79–1.02) 0.090
Infiltrative changes on x-ray     
 No 1.00    
 Yes 0.74 (0.33–1.67) 0.470   
Cavitary changes on x-ray     
 No 1.00   1.00  
 Yes 1.25 (0.89–1.74) 0.191 1.76 (1.08–2.85) 0.023*
Fibrotic changes on x-ray     
 No 1.00    
 Yes 1.17 (0.71–1.91) 0.527   
Other Opportunistic Infections     
 No 1.00   1.00  
 Yes 2.54 (1.82–3.55) <0.001* 1.80 (1.10–2.94) 0.019*
Comorbidity     
 No 1.00   1.00  
 Yes 3.97 (2.64–5.97) <0.001* 2.26 (1.20–4.27) 0.012*
Adverse events     
 No 1.00   1.00  
 Yes 1.45 (1.04–2.02) 0.028* 1.09 (0.68–1.77) 0.720
Regimen type at baseline     
 Standardised 1.00    
 Modified individualised 1.55 (1.10–2.19) 0.013*   
  1. OR Odds ratio, 95 % CI (Confidence interval)
  2. aUnadjusted model
  3. bAdjusted for BMI, haemoglobin, CD4, and other opportunistic infections
  4. *Significant p <0.05