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Table 3 Patient characteristics and other factors evaluated for their associations with serological outcomes after syphilis therapy

From: A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy

First Author PatientAge Patient Gender Baseline nontrepo-nemal titers Stage of syphilis infection History of prior syphilis Trepo-nemal IgM Syphilis treatment regimen HIV coinfection CD4 cell count HIV viral load Antiretroviral therapy
Dionne-Odom   + + +       
Fiumara    +         
Ghanem (2007) [23]        +    
Goemen           
Knaute     +       
Li    + +   +      
Long    +       
Manavi   +   +     
Reidner + +      
Rolfs       +    
Romanowski + + +       
Seña +   + +      
Tittes + +    +    
Tong + + + +        
Ghanem (2008) [24] +       H + +
Jinno   + +   H +
Malone         H   
Tsai +      H
Wu   +     H
Yang    + +   + H
  1. H indicates that the study included HIV-infected participants only
  2. + indicates a significant association in multivariate analyses between the variable and serological outcomes after therapy
  3. – indicates that a significant association was not identified between the variable and serological outcomes after therapy