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Table 1 Study design and characteristics of the study population among 20 studies included in the systematic review

From: A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy

First author Study design Study time period Study location Number of study subjects Study population Male sex (%) Men who have sex with men (%) HIV prevalence (%) Primary syphilis (%) Secondary syphilis (%) Early latent syphilis (%) Late latent syphilis (%) Tertiary or neuro-syphilis (%)
Dionne-Odom R cohort 2002–2008 Lusaka, Zambia and Kigali, Rwanda 1321 HIV-serodiscordant couples 40 NR 70.6 NR NR NR
Fiumara R cohort NR Boston, Massachusetts (US) 128 University hospitals 64 NR NR 0 0 0 100 NR
Ghanem (2007) [23] R cohort 1992–2000 Baltimore, Maryland (US) 297 STD clinic 44 NR 43.4 62.6 37.4 0
Ghanema (2008) [24] R cohort 1990–2006 Baltimore, Maryland (US) 180 University HIV clinic 67.2 NR 100 26.8b 55.4b 17.8b
Goemenb P cohort NR Kinshasa, Zaire 193 Women’s health center 0 0 37 NR NR NR
Jinno R cohort 2006–2011 Los Angeles, California (US) 560 Urban HIV clinics 99 96.7 100 14 26 60 0 0
Knautec R cohort 1999–2008 Zurich, Switzerland 264 University and general hospitals 92 NR 42 34 50 13d 3
Li R cohort 2000–2010 Beijing, China 501 University hospital 50.9 NR 0 17.4 51.1 31.5 0 0
Longe P cohort 2003 Lima, Peru 96 Neighborhood venues NR NR 15.6 NR NR NR
Malonef R cohort 1985–1991 San Diego, California (US) 100 Naval Medical Center 99e NR 100 3.6 16.1 17.9 53.6 8.9
Manavig P cohort 2003–2005 Birmingham UK 261 STD clinics 76f 38.3 38.3 0 0 100 0 0.4
Reidner P RCT 2000–2003 Myeba Region, Tanzania 328 High risk populations 28.4 NR 52.1 7.6 0 92.8 0 0
Rolfs P RCT 1991–1994 NR 541 NR 70.8 12.8 18.7 25.7 46.8 27.5 0 HIV+: 61 %
HIV-: 40 %
Romanowski R cohort 1981–1987 Alberta, Canada 882 Provincial public health records 17 21.1 NR 68.3 18.3 4.3 0 NR
Seña P RCT 2000–2009 Birmingham New Orleans, Los Angeles, Baltimore, Durham, Raleigh, Indianapolis, (US); Antana-narivo Tamatave, Madagascar 465 STD clinics 61.7 3.0 0 24.7 46.9 28.4 0 0
Tittesh R cohort 1987–2010 Vienna, Austria 249 University STD-outpatient clinic 83.1   31.7 26.1 73.9 0 0 0
Tong R cohort 2005–2010 Xiamen, China 1327 University hospital 58.9 NR 0 22.0 27.1 31.4i 19.5d
Tsai R cohort 2007–2013 Taiwan 394 HIV care hospitals 100 94.9 100 8.9 55.3 35.8 0 0
Wuj P cohort 2009–2013 Taiwan 174 University hospital 99.7 97.0 100 17.6 53.7 28.7 0 0
Yang P cohort 2007–2012 Taiwan 573 HIV care hospitals NR 94.1 100 8.9 57.8 33.3 0 0
  1. R retrospective, P prospective, RCT randomized controlled trial, NR not reported
  2. a Demographics and serological outcome data were reported for 180 patients; however, syphilis stages were reported for 231 cases of syphilis
  3. b Demographics were reported for 193 patients; however, serological outcome data were reported for 120 patients
  4. c Demographics and syphilis stages were reported for 264 patients; however, serological outcome data were reported for 214 patients
  5. d This value is the total percentage of latent syphilis patients. This study did not distinguish between early latent and late latent patients
  6. e Demographics were reported for 96 patients; however, serological outcome data were reported for 76 patients
  7. f Demographics and syphilis stages were reported for 100 patients; however, serological outcome data were reported for 56 patients
  8. g Demographics and syphilis stages were reported for 371 patients; however, serological outcome data were reported for 261 patients
  9. h Demographics and syphilis stages were reported for 379 patients; however, serological outcome data were reported for 249 patients
  10. i This value is the total percentage of latent syphilis patients. This study did not distinguish between early latent and late latent patients
  11. j Demographics and syphilis stages were reported for 296 patients; however, serological outcome data were reported for 174 patients