Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study

Table 1 Health resource utilisation considered in derivation of cost of HCV Health-states

Input	Mild	Mod	Comp. Cirrhosis	Decomp. Cirrhosis	HCC	Transplant Year 1	Transplant > Year 1	SVR	Source
OPD bundle^a	✓	✓	✓	✓	✓	✓	✓	✓	Institution costs
FBC
Renal profile
Liver profile
Coagulation screen
AFP
HCV Viral load
Liver US
Staff Costs									HSE salary scale 2010
Liver Biopsy	✓	✓	✓	✕	✕	✕	✕	✕	HSE DRG 2011
OGD^b	✕	✕	✓	✓	✓	✕	✕	✕	HSE DRG 2011
Hepatology Medical review	✓	✓	✓	✓	✓	✓	✓	✓	Micro-costing
Hepatology Nursing review	✓	✓	✓	✓	✓	✕	✕	✕	Micro-costing
Inpatient Admission	✕	✕	✓	✓	✓	✓	✓	✕	HSE DRG 2011
Sorafenib	✕	✕	✕	✕	✓	✕	✕	✕	Micro-costing^d
TACE^c	✕	✕	✕	✕	✓	✕	✕	✕	Institution cost
Oncology/ Palliative OPD	✕	✕	✕	✕	✓	✕	✕	✕	HSE DRG 2011
Dermatology OPD	✕	✕	✕	✕	✕	✓	✓	✕	HSE DRG 2011
Hepatology Dayward review	✕	✕	✕	✕	✕	✓	✓	✕	HSE DRG 2011
Pre-transplant workup	✕	✕	✕	✕	✕	✓	✕	✕	Micro-costing
3 months Prophylaxis	✕	✕	✕	✕	✕	✓	✕	✕	Micro-costing^d
Immunosuppression	✕	✕	✕	✕	✕	✓	✓	✕	Micro-costing^d
Diuretic/Beta-blocker	✕	✕	✓	✓	✕	✕	✕	✕	Micro-costing^d

Mod moderate, Comp. cirrhosis Compensated cirrhosis, Decomp. Cirrhosis decompensated cirrhosis, HCC hepatocellular carcinoma, Transplant Year 1 First 12 months of liver transplantation, Transplantation > Year 1 Transplantation After First 12 months, SVR Sustained Viral Response, HSE Health Service Executive, DRG Diagnostic Related Group, PCRS Patient Care Reimbursement Service, OPD outpatient, ^aBundle: FBC Full Blood Count, Renal Profile Urea, Creatinine, Sodium, Potassium, Bicarbonate; Liver Profile Albumin, Alanine amino transaminase, Aspartate amino transaminase, Gamma glutamyl transferase, Bilirubin, Lactate Dehydrogenase; Coagulation Screen Prothrombin Time, Activated partial thromboplastin time, International Normalised Ratio, AFP Alpha fetoprotein, ^bOGD Oesophago-gastro-duodenoscopy, ^cTACE Transarterial chemoembolisation, ^dUnit cost of drug sourced from the Primary Care Reimbursement System

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