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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: The potential of a multiplex high-throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study

Fig. 1

Schematic presentation of the modeled scenarios. Legend/footnote: Scenarios: a. = Rapid test following culture; b. Improved analytical sensitivity; c. Improved clinical accuracy; TB = pulmonary tuberculosis; DR = drug resistance; Sm + =sputum smear positive; Sm- = sputum smear negative; LiPA1 = Line Probe Assay for first-line drugs; Xpert = Xpert MTB/RIF assay; MRD = Molecular resistance detection; MGIT = Mycobacterial Growth Inhibitor Tube; LJ = Löwenstein-Jensen; DST = Drug Susceptibility Testing; SUS = susceptible TB; INH mono = isoniazide mono resistance; RR = rifampicin resistance; MDR = multi-drug resistance, defined as resistance to rifampicin and isoniazid; XDR = extensively drug-resistant tuberculosis; PDR = poly drug resistance (to first-line drugs but not rifampicin)

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