Effect of isoniazid preventive therapy on immune responses to mycobacterium tuberculosis: an open label randomised, controlled, exploratory study

Table 3 The impact of isoniazid preventive therapy on the net log10 transformed M.tb specific-antibody concentration at the end of six months follow up among household contacts with latent tuberculosis infection

Antibody	Geometric Mean at the end of six months	Geometric Mean at the end of six months	Adjusted geometric mean ratio (bootstrap 95 % CI)^a	P-value
	No IPT (n = 17)	IPT (n = 18)
PPD	3.7(3.5, 4.0)	3.6(3.4, 3.8)	1.03(0.76, 1.40)	0.82
CFP-10	3.6(3.3, 3.9)	3.4(3.3, 3.5)	0.58(0.35, 0.98)	0.04
ESAT-6	3.6(3.4, 3.9)	3.5(3.4, 3.7)	0.87(0.65, 1.18)	0.60

^aThis is the ratio of the expected value of the geometric mean antibody level at six months comparing participants who received IPT to those who did not receive IPT, adjusting for the baseline level of the antibody and the BCG scar status. Each antibody was analysed in a separate model

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