Table 2 The impact of isoniazid preventive therapy on the net cytokine responses at the end of six-months follow up among household contacts with latent tuberculosis infection
Cytokine | Mean at end of six months | Mean at end of six months | Adjusted mean difference at the end of six monthsa | P-value |
|---|---|---|---|---|
| Â | (pg/ml; 95Â % CI) | (pg/ml; 95Â % CI) | (pg/ml; 95Â % CI) | Â |
|  | No IPT (n = 17) | IPT (n = 18) |  |  |
IFN-γ | 2003.6(372.7, 3634.4) | 541.1 (290.8, 791.3) | −1488.6(−2682.5, −294.8) | 0.01 |
IL-2 | 337.0(167.3, 506.8) | 193.9 108.5, 279.3) | −213.1(−419.2, −7.0) | 0.04 |
TNF-α | 34.4(−10.6, 79.4) | 55.6(−6.3, 117.6) | 34.1(−40.0, 108.2) | 0.36 |
IL-5 | 15.5(−3.8, 34.9) | 1.1(0.8, 1.4) | −21.2 (−53.9, 11.3) | 0.20 |
IL-13 | 35.4(−3.2, 74.2) | 5.1(0.9, 9.4) | −45.4(−104.4, 13.4) | 0.13 |
IL-10 | 1.0(0.9, 1.1) | 3.3(−0.8, 7.6) | 2.0 (−1.43, 5.4) | 0.25 |
IL-17a | 2.4(−0.4, 5.2) | 1.5(0.7, 2.3) | 0.4 (−0.4, 1.2) | 0.33 |
IL-17f | 12.3(3.3, 21.3) | 10.2(−6.1, 26.6) | −5.8(−17.5, 5.7) | 0.32 |
IL-21 | 34.0(−22.7, 90.7) | 123.8(−133.9, 381.6) | −11.6(−40.9, 17.5) | 0.43 |
IL-22 | 27.0(1.3, 52.7) | 6.1(−0.2, 12.6) | −6.8(−88.8, 75.0) | 0.86 |