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Table 4 Proportion of S. pneumoniae and H. influenzae (%) with reduced antimicrobial susceptibility. Bacteria isolated in first half of study (1996–2000) were compared to those from the second half of study (2001–2005). Yates chi-square test was used to compare the proportion of strains that were resistant in the first half of the study period (1996–2000) with that in the second half of the study period (2001–2005)

From: Streptococcus pneumoniae and Haemophilus influenzae in paediatric meningitis patients at Goroka General Hospital, Papua New Guinea: serotype distribution and antimicrobial susceptibility in the pre-vaccine era

 

1996–2000

2001–2005

P value

S. pneumoniae

   

 Penicillin

29/116 (25.0)

9/61 (14.8)

0.12

 Chloramphenicol

1/115 (0.9)

3/61 (4.9)

0.09

 Cotrimoxazole

9/116 (7.8)

6/60 (10.0)

0.64

 Tetracycline

2/69 (2.9)

2/27 (7.4)

0.32

H. influenzae

   

 Ampicillin

27/104 (26.0)

27/58 (46.6)

0.01

 Chloramphenicol

27/104 (26.0)

24/58 (41.4)

0.04

 Cotrimoxazole

35/104 (33.7)

28/58 (48.3)

0.07