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Table 2 Rotavirus-associated MERS in children: review of the literature

From: Rotavirus-associated mild encephalopathy with a reversible splenial lesion (MERS)—case report and review of the literature

Author, year, location, reference, Sex, age (years) Prodromal symptoms Interval to initial neurological symptom (days) CNS symptoms Serum Na (mEq/l) Stool detection of RV Serum detection of RV CSF detection of RV Interval to disappearance of SCC lesion (days) EEG findings Treatment Outcome
Kobata et al, 2002 Japan [8] F, 2 Fever, diarrhoea, vomiting 2 DC (24 h), seizures 136 (+) G1 NE NE 5 NE Diazepam PR one dose NS
Isotonic fluids
Natsume et al, 2006 Japan [12] F, 2 Diarrhoea, vomiting 3 Cluster of seizures Normal (+) NE NE 9 NAD Diazepam PR one dose, phenobarbital IM one dose NS
Fukuda et al, 2009 Japan [10] M, 2 Fever, diarrhoea, vomiting 3 DC (24 h) 130 (+) G3 NE (–) 5 GDSW Midazolam infusion 0.1 mg/kg/h for 1 day NS
Methylprednisolone 24 mg/kg/day for 3 days
Kato et al, 2009 Japan [9] F, 1 Fever, diarrhoea, vomiting 4 Seizures 137 (+) NE (–) 6 Spikes and slow waves in the right occipital area Diazepam NS
Jang and Lee, 2010 Korea [16] F, 2 Fever, diarrhoea, vomiting 2 Seizures 138 (+) NE NE 6 NAD Empiric antibiotics, aciclovir NS
Isotonic fluids
Arakawa et al, 2011 Japan [11] M, 3 Diarrhoea, vomiting 3 DC (24 h) 128 (+) G9P[8] (–) NE 6 NE Osmotic diuretic, isotonic fluids NS
Arakawa et al, 2011 Japan [11] M, 3 Fever, vomiting 3 DC (24 h) 129 (+) G3P[8] (+) G3 NE 7 NE Osmotic diuretic, isotonic fluids NS
Fuchigami et al, 2013 Japan [15] F, 4 Fever, diarrhoea, vomiting 4 DC (6 days), seizures 140 (+) G1P[8] (+) G1 (–) 7 GDSW Osmotic diuretic, isotonic fluids NS
Methylprednisolone 30 mg/kg/day for 3 days
Matsuoka et al, 2013 Japan [17] M, 4 Diarrhoea, vomiting 4 DC (7 h), seizures 132 (+)/ G5P[6] (–) (–) 8 NAD No treatment NS
Yokoyama et al, 2013 Japan [13] M, 2 Fever, diarrhoea, vomiting 2 Seizures Normal (+) NE (–) 9 NAD Phenobarbital PO for 9 days NS
Kashiwagi et al, 2014 Japan [19] M, 5 Fever, diarrhoea, vomiting 1 DC (32.5 h) 133 (+) ND ND ND GDSW Methylprednisolone for 3 days NS
Mazur-Melewska et al, 2015 Poland [14] F, 6 Diarrhoea, vomiting 2 Cluster of seizures, DC 137 (+) NE NE 12 Slowed waves in the posterior occipito-temporal area Dexamethasone NS
0.4 mg/kg/day for 5 days
Isotonic fluids
Pan et al, 2015 China [18] F, 2 Fever, diarrhoea, vomiting ND Seizures (twice) 134 (+) ND ND 5 NAD Methylprednisolone pulse and oral prednisolone NS
Osmotic diuretic, isotonic fluids
Present case M, 4 Fever, diarrhoea, vomiting 3 DC (24 h) 131 (+) G1P[8] NE (–) NE GDSW, more prominent in the right hemisphere Ceftriaxone, clarithromycin, aciclovir for 5 days NS
Isotonic fluids
  1. Abbreviations: DC disturbance of consciousness; GDSW global diffuse slow waves; NAD nothing abnormal detected; ND not documented; NE not examined; NS no sequelae