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Table 2 Fold changes in mRNA levels of immune mediators altered in African AIDS patients and in patients with IBD

From: CD14+ macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide

 

HIV vs. Controls

CD vs. Controls

UC vs. Controls

FC

p-value

FC

p-value

FC

p-value

Cytokines and Chemokines

IFN-γ

5.31

0.001

4.81

0.037

1.02

0.667

TNF-α

7.11

0.005

14.27

0.001

13.65

0.001

IL-1β

4.27

0.050

12.97

0.032

59.26

0.049

IL-8

7.24

0.212

36.84

0.075

194.5

0.002

IL-10

3.03

0.376

4.19

0.123

5.44

0.012

IL-18

26.85

0.031

32.17

0.004

28.57

0.001

TGF-β1

2.55

0.542

3.46

0.029

4.04

0.045

CCL2

10.78

0.008

16.07

0.007

59.33

0.009

CCL22

1.40

0.697

3.61

0.043

1.94

0.491

CXCL2

1.77

0.387

2.25

0.447

3.23

0.097

Receptors

ICAM1

4.31

0.231

14.17

0.008

31.75

0.001

IL12Rβ1

3.69

0.017

4.06

0.026

3.42

0.045

TLR4

3.28

0.192

5.05

0.211

6.16

0.042

IL6R

1.09

0.782

1.14

0.541

0.66

0.037

IL17RE

0.64

0.521

0.67

0.245

0.38

0.041

IL17Rβ

0.76

0.469

0.27

0.037

0.15

0.006

Transcription Factors

TRAF6

14.75

0.014

12.77

0.027

12.81

0.049

SOCS1

2.29

0.512

4.24

0.076

8.27

0.029

SOCS3

1.96

0.341

5.52

0.023

20.31

0.005

S1PR1

3.12

0.231

4.29

0.049

7.15

0.009

TBX21

5.73

0.012

4.04

0.038

2.53

0.234

YY1

11.91

0.046

5.84

0.071

7.97

0.001

CLEC7

2.09

0.432

2.49

0.381

4.84

0.043

  1. IFN-γ Interferon-γ, TNF-α Tumour Necrosis Factor-α, IL Interleukin, TGF-β1 Transforming Growth Factor-β1, CCL Chemokine (C-C motif) ligand, CXCL chemokine (C-X-C motif) ligand, TLR Toll-like receptors, SOCS suppressor of cytokine signaling proteins, TRAF TNF receptor associated factor, TBX T-box transcription factor, YY Yin Yang, CLEC C-type lectin domain family
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BMC Infectious Diseases

ISSN: 1471-2334

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