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Table 2 Fold changes in mRNA levels of immune mediators altered in African AIDS patients and in patients with IBD

From: CD14+ macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide

  HIV vs. Controls CD vs. Controls UC vs. Controls
FC p-value FC p-value FC p-value
Cytokines and Chemokines IFN-γ 5.31 0.001 4.81 0.037 1.02 0.667
TNF-α 7.11 0.005 14.27 0.001 13.65 0.001
IL-1β 4.27 0.050 12.97 0.032 59.26 0.049
IL-8 7.24 0.212 36.84 0.075 194.5 0.002
IL-10 3.03 0.376 4.19 0.123 5.44 0.012
IL-18 26.85 0.031 32.17 0.004 28.57 0.001
TGF-β1 2.55 0.542 3.46 0.029 4.04 0.045
CCL2 10.78 0.008 16.07 0.007 59.33 0.009
CCL22 1.40 0.697 3.61 0.043 1.94 0.491
CXCL2 1.77 0.387 2.25 0.447 3.23 0.097
Receptors ICAM1 4.31 0.231 14.17 0.008 31.75 0.001
IL12Rβ1 3.69 0.017 4.06 0.026 3.42 0.045
TLR4 3.28 0.192 5.05 0.211 6.16 0.042
IL6R 1.09 0.782 1.14 0.541 0.66 0.037
IL17RE 0.64 0.521 0.67 0.245 0.38 0.041
IL17Rβ 0.76 0.469 0.27 0.037 0.15 0.006
Transcription Factors TRAF6 14.75 0.014 12.77 0.027 12.81 0.049
SOCS1 2.29 0.512 4.24 0.076 8.27 0.029
SOCS3 1.96 0.341 5.52 0.023 20.31 0.005
S1PR1 3.12 0.231 4.29 0.049 7.15 0.009
TBX21 5.73 0.012 4.04 0.038 2.53 0.234
YY1 11.91 0.046 5.84 0.071 7.97 0.001
CLEC7 2.09 0.432 2.49 0.381 4.84 0.043
  1. IFN-γ Interferon-γ, TNF-α Tumour Necrosis Factor-α, IL Interleukin, TGF-β1 Transforming Growth Factor-β1, CCL Chemokine (C-C motif) ligand, CXCL chemokine (C-X-C motif) ligand, TLR Toll-like receptors, SOCS suppressor of cytokine signaling proteins, TRAF TNF receptor associated factor, TBX T-box transcription factor, YY Yin Yang, CLEC C-type lectin domain family