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Fig. 6 | BMC Infectious Diseases

Fig. 6

From: CD14+ macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide

Fig. 6

Depletion of CD14+ macrophages leads to a marked decrease in the ability of MMC to produce TNF and IL-6, both constitutively and in response to LPS stimulation. CD14+ macrophages were depleted from MMC isolated from the colon of ART-naïve AIDS patients. Total (CD14+) and CD14-depleted MMC were then cultured for 18 h in the presence or absence of LPS. Cytokine/chemokine secretion into the culture supernatant was quantified using customized Bio-Plex plates. Results represent the mean ± SD of triplicate assays performed on 10 African patients with AIDS. Statistical significance between groups was calculated using the Mann–Whitney U test. Statistically significant differences (p < 0.05) are indicated by an asterisk

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