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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: CD14+ macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide

Fig. 1

Inflammation in the colon of AIDS patients occurs in the setting of severe T cell dysregulation. a Differences in the frequency of CD4+ T in the colon of AIDS patients (n = 23) relative to uninfected healthy controls (n = 5) and IBD patients (n = 5) as determined by IHC. b Increased number of CD8+ T cells in the colon of AIDS patients relative to controls (p = 0.016) and patients with IBD (p = 0.019), as determined by IHC. Graphs show the median values and statistical significance between groups as calculated by Kruskal-Wallis with Dunn’s post-test. c Representative IHC staining showing increased levels of IL-1β in the colon of AIDS patients vs. uninfected controls (p = 0.04). d IHC staining showing increased TNF-α expression in the colon of AIDS patients compared to controls (p = 0.01)

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