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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Impact of naturally occurring amino acid variations on the detection of HIV-1 p24 in diagnostic antigen tests

Fig. 1

Detection of wildtype and mutated VLPs by diagnostic tests. VLPs were diluted to 10 IU/ml in negative human plasma and analysed with the indicated diagnostic tests. Panels a, b and d show antigen detection results of wildtype (wt) and mutated VLPs for those diagnostic tests which failed to detect wildtype VLPs harbouring the S16T (a and b) or K170R/N variant (d). Panels c and e show results of antigen detection by the Abbott Architect HIV Ag/Ab Combo to control for the presence of p24 antigen. Lines indicate S/Co = 1, which represents the lower limit of S/Co ratios for unequivocally positive samples according to the manufacturer’s instructions. In case of the bioMérieux VIDAS HIV p24 II the line indicates 3 pg/ml, denoting the lower limit of the quantifiable range for this test

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