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Table 1 Summary of typhoid fever vaccines [6, 1316]

From: Typhoid fever cases in the U.S. military

Typhoid vaccine

Route

3-year efficacy

Booster

Adverse reactions

Local

Systemic

Vi Polysaccharide

Parenteral

30–70 %

2 years

10–40 %

2 %

Live Ty21a

Oral

34–58 %

5 years

NA

<1 %

Parenteral heat-phenol inactivated

Parenteral

51–77 %

3 years

10–50 %

10–20 %

Acetone-inactivated

Parenteral

75–94 %

Not applicable

10–50 %

10–20 %