Skip to main content

Table 3 The overall sensitivity and specificity of the LAM test and stratified by subpopulation

From: Diagnostic accuracy of the rapid urine lipoarabinomannan test for pulmonary tuberculosis among HIV-infected adults in Ghana–findings from the DETECT HIV-TB study

LAM test overall Total Microbiological reference standard Composite reference standard
Sensitivity Specificity Sensitivity Specificity
N % (95 % CI) p-value N % (95 % CI) p-value N % (95 % CI) p-value N % (95 % CI) p-value
469 24/55 44 (30–58)   393/414 95 (92–97)   36/100 36 (27–46)   360/369 98 (95–99)  
  By Department 469             
   Inpatient 70 10/15 67 (38–88)   47/55 86 (73–94)   17/40 43 (27–59)   29/30 97 (83–100)  
   Out patient 399 14/40 35 (21–52) 0.035 346/359 96 (94–98) 0.001 19/60 32 (20–45) 0.269 331/339 98 (95–99) 0.74
  By CD4 strata* 454             
   CD4 < 100 195 14/29 48 (29–68)   148/166 89 (83–93)   24/57 42 (29–56)   130/138 94 (89–98)  
   CD4 > = 100 259 8/24 33 (16–55) 0.272 233/235 99 (97–100) <0.001 9/39 23 (11–39) 0.054 219/220 100 (98–100) 0.002
  By MEWS 469             
   MEWS > 4 101 20/35 57 (39–74)   54/66 82 (70–90)   29/54 54 (40–67)   44/47 94 (83–99)  
   MEWS < = 4 368 4/20 20 (6–44) 0.008 339/348 97 (95–99) <0.001 7/46 15 (6–29) <0.001 316/322 98 (96–99) 0.061
  By Vital status at 60 days** 397             
   Dead 52 10/14 71 (42–92)   33/38 87 (72–96)   14/29 48 (29–68)   22/23 96 (78–100)  
   Alive 345 11/34 32 (17–51) 0.013 302/311 97 (95–99) <0.001 14/58 24 (14–37) 0.023 281/287 98 (96–99) 0.483
  1. *15 participants with missing values for CD4 were excluded from analysis
  2. **63 participants were lost to follow-up at 2 months and 7 transferred out
  3. MEWS = Modified Early Warning Score