Diagnostic accuracy of the rapid urine lipoarabinomannan test for pulmonary tuberculosis among HIV-infected adults in Ghana–findings from the DETECT HIV-TB study

Table 3 The overall sensitivity and specificity of the LAM test and stratified by subpopulation

		Total	Microbiological reference standard						Composite reference standard
			Sensitivity			Specificity			Sensitivity			Specificity
			N	% (95 % CI)	p-value	N	% (95 % CI)	p-value	N	% (95 % CI)	p-value	N	% (95 % CI)	p-value
		469	24/55	44 (30–58)		393/414	95 (92–97)		36/100	36 (27–46)		360/369	98 (95–99)
By Department		469
	Inpatient	70	10/15	67 (38–88)		47/55	86 (73–94)		17/40	43 (27–59)		29/30	97 (83–100)
	Out patient	399	14/40	35 (21–52)	0.035	346/359	96 (94–98)	0.001	19/60	32 (20–45)	0.269	331/339	98 (95–99)	0.74
By CD4 strata*		454
	CD4 < 100	195	14/29	48 (29–68)		148/166	89 (83–93)		24/57	42 (29–56)		130/138	94 (89–98)
	CD4 > = 100	259	8/24	33 (16–55)	0.272	233/235	99 (97–100)	<0.001	9/39	23 (11–39)	0.054	219/220	100 (98–100)	0.002
By MEWS		469
	MEWS > 4	101	20/35	57 (39–74)		54/66	82 (70–90)		29/54	54 (40–67)		44/47	94 (83–99)
	MEWS < = 4	368	4/20	20 (6–44)	0.008	339/348	97 (95–99)	<0.001	7/46	15 (6–29)	<0.001	316/322	98 (96–99)	0.061
By Vital status at 60 days**		397
	Dead	52	10/14	71 (42–92)		33/38	87 (72–96)		14/29	48 (29–68)		22/23	96 (78–100)
	Alive	345	11/34	32 (17–51)	0.013	302/311	97 (95–99)	<0.001	14/58	24 (14–37)	0.023	281/287	98 (96–99)	0.483

ISSN: 1471-2334