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Table 2 Overall performance of LAM test for diagnosis of tuberculosis

From: Diagnostic accuracy of the rapid urine lipoarabinomannan test for pulmonary tuberculosis among HIV-infected adults in Ghana–findings from the DETECT HIV-TB study

  Total Sensitivity Specificity LR (+) LR (−) PPV NPV
N % (95 % CI) N % (95 % CI) (95 % CI) (95 % CI) % (95 % CI) % (95 % CI)
LAM test overall          
Microbiological reference standard* 469 24/55 44 (30–58) 393/414 95 (92–97) 8.6 (5.1-14.4) 0.6 (0.5-0.8) 53 (38–68) 93 (90–95)
Composite reference standard** 469 36/100 36 (27–46) 360/369 98 (95–99) 14.8 (7.4-29.6) 0.7 (0.6-0.8) 80 (65–90) 85 (81–88)
  1. *Primary analysis using a microbiological reference standard:” Confirmed TB” cases versus culture and Xpert negative cases
  2. **Secondary analysis using a composite reference standard: “Confirmed TB” and “Possible TB” combined for calculations of sensitivity versus “Non TB”
  3. LR (+) = Positive Likelihood Ratio, LR (−) = Negative Likelihood Ratio, PPV = Positive Predictive Value, NPV = Negative Predictive Value
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