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Table 2 Laboratory test results. Laboratory parameters on admission of 153 hospitalized adults with dengue by dengue severity according to the WHO’s 2009 definition

From: Identification of clinical factors associated with severe dengue among Thai adults: a prospective study

Characteristics

Severe dengue (n = 21)

Non-severe dengue (n = 132)

p-value

# (%)

# (%)

Confirmation tests for dengue

   

Known dengue RT-PCR (n = 88)

  

0.765

 Serotypes 1 or 4

4 (19.0)

25 (18.9)

 

 Serotypes 2 or 3

11 (52.4)

48 (36.4)

 

Known serological response to infection (n = 144)

  

0.551

 Primary dengue infection

1 (4.8)

4 (3.0)

 

 Secondary dengue infection

20 (95.2)

119 (90.2)

 

Complete blood counts

   

Hemoglobin, median (IQR), g/dL

14.0 (12.5–16.6)

13.8 (12.8–14.9)

0.627

Hematocrit, median (IQR), %

41.7 (36.7–48.5)

41.1 (38.3–44.4)

0.934

WBC, median (IQR), ×103 cells per μL

4.7 (2.4–10.5)

3.1 (2.3–4.6)

0.034

Absolute band form, median (IQR), cells per μL

188 (87–372)

142 (60–666)

0.237

Absolute PMN, median (IQR), cells per μL

2320 (1210–4126)

1620 (873–2264)

0.055

Absolute LYM, median (IQR), cells per μL

940 (405–2011)

758 (546–1126)

0.509

Absolute ALYM, median (IQR), cells per μL

684 (108–1370)

138 (68–379)

0.011

Platelet counts, median (IQR) × 103 per μL

56.0 (12.0–71.0)

85.0 (56.0–136.2)

<0.001

Categorical data

   

Hematocrit

  

0.928

  ≤ 2 % above reference range

7 (33.3)

49 (37.1)

 

  > 2 % above reference range

14 (66.7)

83 (62.9)

 

Absolute band form

  

1.000

  ≤ 250 cells per μL

15 (71.4)

97 (73.5)

 

  > 250 cells per μL

6 (28.6)

35 (26.5)

 

Absolute PMN

  

0.422

  < 1500 cells per μL

7 (33.3)

60 (45.5)

 

  ≥ 1500 cells per μL

14 (66.7)

72 (54.5)

 

Absolute LYM

  

0.036

  ≤ 2000 cells per μL

16 (76.2)

122 (92.4)

 

  > 2000 cells per μL

5 (23.8)

10 (7.6)

 

Absolute ALYM

  

0.002

  ≤ 300 cells per μL

8 (38.1)

99 (75.0)

 

  > 300 cells per μL

13 (61.9)

33 (25.0)

 

Platelet counts

  

0.031

  ≤ 100 × 103 per μL

18 (85.7)

77 (58.3)

 

  > 100 × 103 per μL

3 (14.3)

55 (41.7)

 

Blood chemistries

   

Creatinine, median (IQR), mg/dL

0.8 (0.6–1.1)

0.8 (0.6–1.0)

0.739

Lactate level, median (IQR), mmol/L

2.7 (1.7–3.1)

1.4 (1.2–1.8)

<0.001

Albumin, median (IQR), g/dL

3.7 (3.2–4.3)

4.3 (4.0–4.5)

<0.001

AST, median (IQR), IU/L

219 (94–692)

76 (37–158)

<0.001

ALT, median (IQR), IU/L

100 (61–346)

47 (18–106)

0.003

Categorical data

   

Lactate level

  

<0.001

  < 2.0 mmol/L

7 (33.3)

111 (84.1)

 

  ≥ 2.0 mmol/L

14 (66.7)

21 (15.9)

 

Albumin

  

<0.001

  < 3.5 g/dL

13 (61.9)

128 (97.0)

 

  ≥ 3.5 g/dL

8 (38.1)

4 (3.0)

 

AST

  

0.017

  ≤ 120 IU/L

7 (33.3)

84 (63.6)

 

  > 120 IU/L

14 (66.7)

48 (36.4)

 

ALT

  

0.032

  ≤ 120 IU/L

11 (52.4)

102 (77.3)

 

  > 120 IU/L

10 (47.6)

30 (22.7)

 
  1. Abbreviations: RT-PCR reverse-transcriptase polymerase chain reaction, IQR interquartile range, WBC white blood cell counts, PMN neutrophils, LYM lymphocytes, ALYM atypical lymphocytes, AST aspartate aminotranferase, ALT alanine aminotransferase
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BMC Infectious Diseases

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