Table 3 Diagnostic accuracy of the Kalon HSV-2 IgG ELISA compared to UW-WB in South African and Zambian sera (N = 600) a
Characteristic | Country of origin | HIV status | Total (n/N) | ||
|---|---|---|---|---|---|
South Africa | Zambia | HIV negative | HIV positive | ||
HSV-2 Prevalence by UW-WB, % (95Â % CI) | 82.1 (77.2, 86.3) | 81.6 (76.6, 85.9) | 63.9 (58.0, 69.4) | 99.3 (97.6, 99.9) | 81.9 (478/584) |
GUD Presentation by Physical Exam, % (95Â % CI) | 1.4 (0.4, 3.4) | 3.5 (1.7, 6.3) | 0.7 (0.1, 0.2) | 4.1 (2.1, 7.0) | 2.4 (14/583) |
Medical History of GUD in past 3Â months, % (95Â % CI) | 1.7 (0.6, 3.9) | 3.1 (1.4, 5.8) | 0.7 (0.1, 0.2) | 4.1 (2.1, 7.0) | 2.4 (14/583) |
HIV Prevalence, % (95 % CI) | 49.7 (43.8, 55.5) | 51.7 (45.8, 57.6) | – | – | 50.7 (296/584) |
Median Age (IQR) | 31.6 (27.1, 37.4) | 32.2 (27.2, 41.7) | 33.4 (28.0, 39.6) | 31.1 (26.3, 37.6) | 32.0 (27.1, 38.7) |
Kalon Performance (cut-off = 1.1) | |||||
 Sensitivity, % (95 % CI) | 94.2 (90.5, 96.8) | 97.0 (94.0, 98.8) | 94.0 (89.6, 97.0) | 96.6 (93.8, 98.4) | 95.6 (93.4, 97.3) |
 Specificity, % (95 % CI) | 98.1 (89.9, 100.0) | 88.7 (77.0, 95.7) | 94.2 (87.9, 97.9) | – | 93.4 (86.9, 97.3) |
 AUC (95 % CI) | 0.96 (0.94, 0.99) | 0.93 (0.88, 0.97) | 0.94 (0.91, 0.97) | – | 0.95 (0.92, 0.97) |
Kalon Performance (cut-off = 1.5) | |||||
 Sensitivity, % (95 % CI) | 92.2 (88.1, 95.2) | 92.3 (88.2, 95.4) | 88.6 (83.1, 92.8) | 94.6 (91.3, 96.9) | 92.3 (89.5, 94.5) |
 Specificity, % (95 % CI) | 98.1 (89.9, 100.0) | 92.5 (81.8, 97.9) | 96.2 (90.4, 98.9) | – | 95.3 (89.3, 98.5) |
 AUC (95 % CI) | 0.95 (0.93, 0.98) | 0.92 (0.88, 0.96) | 0.92 (0.89, 0.95) | – | 0.94 (0.91, 0.96) |