Skip to main content

Table 3 Performance assessment of multivariable models developed on development subset and validated on validation set (predicting outcomes based on measurements in validation set and comparing with known blood culture result)

From: Blood cultures taken from patients attending emergency departments in South Africa are an important antibiotic stewardship tool, which directly influences patient management

Model name Variables included Percent correctly classified Specificity (95 % CI) NPV (95 % CI) Sensitivity (95 % CI) PPV (95 % CI)
Saturated multivariable model (based on univariate p < 0.15) Malignancy, low systolic, low diastolic, high pulse, CRB 65 score, source 91 % (225/248) 0.98 (0.96, 1.00) 0.92 (0.88, 0.95) 0.05 (0.00, 0.25) 0.02 (0.01, 0.72)
Trimmed multivariable model (drop variables with multivariable p > 0.15) Source, CRB 65 score 91 % (225/248) Same as saturated Same as saturated Same as saturated Same as saturated
Classification tree (only Source used) All variables (continuous version if available) 90 % (225/250) 0.97 (0.94, 0.99) 0.92 (0.88, 0.95) 0.05 (0.00, 0.25) 0.14 (0.00, 0.45)
\